血管生成素-2在结核性和恶性胸腔积液鉴别诊断中的价值

Angiopoietin-2 level in differential diagnosis between tuberculous and malignant pleural effusion

目的探讨血管生成素-2(angiopoietin-2,Ang-2)在结核性和恶性胸腔积液鉴别诊断中的意义。方法采用酶联免疫吸附法(ELISA)检测48例恶性胸腔积液患者和42例结核性胸腔积液患者胸腔积液中Ang-2的含量。结果恶性胸腔积液中Ang-2含量为(48.4±21.5)ng/L,明显高于结核性胸腔积液(20.8±13.6)ng/L,两者比较差异有统计学意义(t=6.817,P<0.05);以31.6 ng/L为临界值,Ang-2对恶性胸腔积液诊断的敏感度为87.5%,特异性为76.2%,准确性为82.2%。结论胸腔积液中Ang-2的测定可作为鉴别结核性和恶性胸腔积液的指标。

Objective To investigate the role of angiopoietin-2（ Ang-2） level in differential diagnosis between tuberculous and malignant pleural effusion. Methods Ang-2 level was detected with enzyme linked immunosorbent assay（ ELISA） in 48 samples of malignant pleural effusion and 42 samples of tuberculous pleural effusion. Results The level of Ang-2 in malignant pleural effusion was significantly higher than that in tuberculous pleura effusion [（ 48. 4 ± 21. 5） ng / L vs（ 20. 8 ± 13. 6） ng / L,t = 6. 817,P 0. 05]. With the cut-off value of 31. 6 ng / L,the sensitivity,specificity and accuracy of Ang-2 for the diagnosis of malignant pleural effusion were 87. 5%,76. 2% and 82. 2%,respectively.Conclusion Ang-2 might be used as an indicator for the differential diagnosis of tuberculous and malignant pleural effusion.