破骨细胞分化调节机制的研究进展

Research on regulation mechanism of osteoclast differentiation

破骨细胞起源于骨髓的单核髓性造血干细胞,是一种具有骨吸收功能的多核巨细胞,其在骨代谢方面起着关键性的作用,因而机体对于破骨细胞的调控非常严格。破骨细胞动员和分化成熟过程是一个复杂而又精细的多级调控过程,在相关调控机制中,OPG/RANKL/RANK系统起着分化调节枢纽的作用,是调节破骨细胞分化和功能的关键信号途径。最近研究发现破骨细胞和免疫细胞在骨代谢领域相互联系紧密,这也为骨疾病的治疗提供了新的治疗靶点。另外破骨细胞凋亡在骨代谢中的作用越来越受重视,但其相关机制还不是很明确,仍需要深入研究。

Osteoclasts are multinucleated giant cell,which derived from mononuclear myeloid hematopoietic stem cells with the function of bone absorption. Osteoclasts plays a key role in bone metabolism,therefore the body is very strict to regulation of osteoclastogenesis. Mobilization and differentiation of osteoclast maturation is a complex and sophisticated multi level regulatory processes. In the relevant regulatory mechanisms,OPG / RANKL / RANK system plays a pivotal role in the process of osteoclast differentiation and maturation. Recent studies revealed that immune cells and osteoclasts were closely connect with each other in the field of bone metabolism,also provide a new therapeutic target for the treatment of bone diseases. The apoptosis of osteoclasts in bone metabolism have been payed more attention,while its mechanism is still not clear,which need further research.