摘要
目的探讨肝细胞肝癌患者血清中可溶性B7-H4和GP73的变化水平及其临床意义。方法应用ELISA法检测80例肝细胞肝癌患者、50例慢性乙肝患者和50例健康对照者B7-H4和GP73水平,并对比分析。结果肝细胞肝癌组、慢性乙型肝炎组和健康对照组血清中B7-H4的水平分别是(51.1±18.6)μg/L,(33.5±9.3)μg/L和(29.6±6.6)μg/L;GP73水平分别是(131.4±35.2)μg/L,(79.5±18.2)μg/L和(75.4±13.9)μg/L。肝细胞肝癌组B7-H4和GP73表达水平高于慢性乙型肝炎组和健康对照组(P均<0.05)。肝细胞肝癌血清B7-H4和GP73的水平与临床分期和肿瘤大小有关(P均<0.05)。结论血清B7-H4和GP73在肝细胞肝癌血清中高表达可鉴别肝脏的良恶性肿瘤,其表达水平与肝细胞肝癌的临床分期和肿瘤大小密切相关。
Objective To analyze the changes of serum soluble B7-H4 （sB7-H4） and Golgi protein 73 in primary hepatocellular carcinoma（HCC） cases and the clinical significance. Methods The expressions of sB7-H4 and GP73 in 80 HCC cases,50 chronic hepatitis cases and 50 normal controls were measured by ELISA. Resuts The serum concentrations of sB7-H4 and GP73 were （51.1±18.6） ug/L, （131.4±35.2）μg/L in the HCC cases, （33.5±9.3） μg/L, （79.5±18.2） ug/L in the chronic hepatits patients and （29.6±6.6） μg/L, （75.4±13.9） μg/L in the normal controls. The concentrations of sB7-H4 and GP73 were significantly higher in HCC cases than those with chronic hepatitis and healthy controls （P〈0.05,respectively）. The expressions of sB7-H4 and GP73 were positively correlated with clinical stage and humor size （P〈0.05,respectively）. Conclusions The serum levels of sB7-H4 and GP73 were upgraded in HCC cases and they are useful for distinguishing benign and malignant liver diseases. The increasing expressions of sB7-H4 and GP73 are correlated with clinical stage and humor size.
出处
《中国热带医学》
CAS
2015年第6期658-660,共3页
China Tropical Medicine
基金
广东省医学科研基金(No.A2014225)
