乳源县瑶族人群乙型肝炎病毒感染危险因素分析

Analysis of risk factors of hepatitis B virus infection among Yao minority nationality in Ruyuan county

目的了解广东省乳源县瑶族人群乙肝病毒(HBV)感染的危险因素。方法采用1:1病例-对照研究的方法,选取乳源县游溪镇的135例瑶族HBV感染者(HBs Ag阳性),同时选取经血液检测未感染HBV的135名瑶族人群作为健康对照,进行入户个案调查乙肝感染相关危险因素。采用单因素分析和条件Logistic回归拟合多因素分析模型综合分析乳源县瑶族人群感染HBV的危险因素。结果单因素分析结果表明,家中有HBV感染者(χ2=40.7179,P=0.00000)、父母为HBV感染者(χ2=29.2423,P=0.00000)、族内通婚(χ2=15.4106,P=0.00009)、共用餐具(χ2=19.5094,P=0.00001)及无乙肝疫苗接种史(χ2=114.8835,P=0.00000)是乳源县瑶族人群感染HBV的危险因素。条件Logistic回归拟合多因素分析模型结果表明,在控制潜在混杂因素的影响后,家中有HBV感染者(OR=8.7286,P=0.0014)、父母为HBV感染者(OR=3.2777,P=0.0174)及乙肝疫苗接种史(OR=16.9909,P=0.0000)对瑶族人群感染HBV有显著影响。结论乳源县瑶族人群HBV感染具有家庭聚集性,家中有HBV感染者、父母为HBV感染者及乙肝疫苗接种史是影响HBV感染的危险因素。

Objective To understand the risk factors of hepatitis B virus （HBV） infection among the population of Yao nationality in Ruyuan county. Methods Case - control study was conducted by selecting 135 Yao minority nationality cases positive for HBV in YOUSI Township （HBsAg＋） and another 135 healthy persons of Yao minority nationality were chosen as control. The risk factors relevant to hepatitis B virus infection were surveyed through case studies among the population of Yao nationality in Ruyuan county and analyzed by univariate and multivariate logistic regression analysis. Results Univariate analysis showed that family members with HBV infection（Xe=40.7179, P=-0.00000）, parents with HBV infection（Xe=29.2423, P=O.OOOOO）,endogamy （Xe=15.4106, P=-O.OOO09）,sharing utensils （22=19.5094, P=-0.O0001）and hepatitis B vaccination history （）t~=114.8835, P=0.00000） were the risk factors of hepatitis B virus （HBV） infection. Multivariate logistic regression analysis showed that after controlling the effect of potential confounding factors, family members with HBV infection （ OR= 8.7286, P=0.0014）,parents with HBV infection （ OR=3.2777, P=0.0174） and hepatitis B vaccination history （ OR =16.9909, P=- 0.0000）were the risk factors of hepatitis B virus （HBV） infection. Gonclusion HBV infection revealed a family clustering trend among the population of Yao minority ationality in Ruyuan county and family members with HBV infection,parents with HBV infection and vaccination history are the risk factors of hepatitis B virus infection.