中青年缺血性脑血管病与高同型半胱氨酸血症的相关性

Correlation of ischemic cerebrovascular disease plasma hyperhomocysteinemia in young and middle aged groups

目的探讨收治的中青年缺血性脑血管病与血浆高同型半胱氨酸血症之间的相关性。方法 2012年1月~2014年11月确诊为脑梗死的中青年患者50例,短暂性脑缺血发作组50例,健康对照组50例,分别于确诊后检查各组的血浆同型半胱氨酸水平,统计高同型半胱氨酸血症的发生率,分析高同型半胱氨酸血症与中青年缺血性脑血管病之间的相关性。结果脑梗死组和短暂性脑缺血发作组中青年患者的同型半胱氨酸明显高于对照组,差异具有统计学意义（P〈0.05）;脑梗死组和短暂性脑缺血发作组中青年患者的高同型半胱氨酸血症的发病率明显高于对照组,差异具有统计学意义（P〈0.05）。结论高同型半胱氨酸血症是中青年人群缺血性脑血管病的独立危险因素,对预测卒中发生风险、判断预后及指导治疗中青年缺血性脑血管病具有积极的作用。

Objective To investigate the correlation of isehemie cerebrovascular disease and plasma hyperhomocysteinemia in young and middle aged groups. Methods The 50 cerebral infarction cases and 50 transient ischemic cases in Qingyuan County People＇s Hospital from January 2013 to November 2014 were chosen as cerebral infarction group and transient ischemie group and another 50 cases as healthy controls. The plasma homocysteine levels in cases of three groups were measured and the incidence of hyperhomocysteinemia was calculated, the correlation of high homocysteine level with ischemic eerebrovascular disease was analyzed. Results The homocystein levels in cases of cerebral infarction group and transient ischemic group were significantly higher than that of control group （P〈0.05）, The hyperhomocysteinemia levels in cases of cerebral infarction group and transient ischemic group was significantly higher than that of the control showing statistically significant difference （P〈0.05）. Conclusion Hyperhomocysteinemia is a independent risk factors for development of cerebrovascular disease in young and middle aged groups and it is also an indicator for prediction of the occurrence of stroke, prognosis and guidance of clinical treatment.