血脂与骨密度:新疆男性高血压患者相关性

Correlation between blood lipid levels and bone mineral density in men with hypertension in Xinjiang

背景:有研究表明绝经后女性血脂与骨密度有一定相关性,但针对男性对象的研究较少,且结论不一。目的:通过分析新疆乌鲁木齐市地区维吾尔族与汉族男性高血压患者血脂与骨密度的关系,探讨血脂水平与骨质疏松及骨量减少的相关性,以及民族间的差异。方法:将193例男性高血压患者,按照民族分为2组,维吾尔族73例,汉族120例,再根据是否合并骨质疏松和骨量减少,将上述2组患者再分别分为2个亚组,分析各组骨密度与血脂的相关性,并用二元Logistic逐步回归方法分析血脂和其他相关因素与骨质疏松之间的相关性。结果与结论:高血压维吾尔族骨质疏松及骨量减少患者中,胆固醇与股骨颈(r=0.43,P=0.01)、Ward三角区(r=0.42,P=0.01)均为正相关,而在汉族高血压患者中未见明显相关性。应用二元Logistic回归方法进行分析,在控制体质量指数、年龄和民族因素后,仅胆固醇与骨质疏松及骨量减少的发生有关(OR=1.48,P=0.03)。结果证实,新疆男性维吾尔族与汉族高血压患者中,血脂与骨密度存在一定相关性,可能为骨质疏松发生的影响因素。

BACKGROUND：Studies have shown that there is a certain correlation between blood lipid levels and bone mineral density in postmenopausal women, but their correlation in men is an open question, which has been less reported. OBJECTIVE：To investigate the relationship between blood lipid levels and bone mineral density in Han and Uygur men with hypertension in Urumqi of Xinjiang Uygur Autonomous Region, as wel as correlation of blood lipid levels with osteoporosis and osteopenia and difference between ethnics. METHODS： A total of 193 male patients with hypertension were categorized into Uygur （n=73） and Han （n=120） groups. Each group was subdivided into osteoporosis or osteopenia group and non-osteoporosis group. Bone mineral density and blood lipid level were analyzed and compared between groups. The correlation between osteoporosis and risk factors was analyzed using logistic regression method. RESULTS AND CONCLUSION：In Uygur hypertension men with osteoporosis or osteopenia, total cholesterol level was positively correlated with the bone mineral density of the femoral neck （r=0.43,P=0.01） and Ward＇s area （r=0.42, P=0.01）; while there were no relationships between blood lipid levels and bone mineral density in Han hypertension men. When a Logistic regression analysis was performed, only total cholesterol level was found to be associated with the presence of osteoporosis or osteopenia after adjustment for body mass index, age and ethnics （OR=1.48,P=0.03）. The blood lipid level is associated with bone mineral density in Han and Uygur men with hypertension from Urumqi of Xinjiang Uygur Autonomous Region, which can affect the presence of osteoporosis.