60岁以上子宫内膜癌临床病理分析

Clinical and pathological analysis of endometrial cancer in patients with ≥60 years old

目的：探讨≥60岁（老年妇女）和〈60岁子宫内膜癌患者的临床病理特征。方法：2000-2010年广东省62家医院确诊子宫内膜癌者10 081例,选取其中手术病理资料较完整者9437例,按年龄分为≥60岁（1774例）和〈60岁组（7663例）。比较两组间的临床病理特点。结果：≥60岁组和〈60岁组的平均发病年龄为（65.5±5.4）岁和（49.6±6.8）岁。≥60岁组的肥胖、糖尿病、高血压比例高于〈60岁组（P〈0.05）。≥60岁组的Ⅱ型子宫内膜癌、G3、p53阳性、淋巴脉管间隙受累、深肌层浸润和腹水细胞学阳性比例高于〈60岁组（P〈0.05）;而PR阳性比例低于〈60岁组（P〈0.05）。两组的ER阳性、宫颈间质浸润、附件转移、淋巴结转移方面比较,差异无统计学意义（P〉0.05）。结论：老年子宫内膜癌患者常具有典型的子宫内膜癌三联征表现,病理危险因素多,更易预后不良。

Objective：To explore the clinical and pathological characteristics of endometrial cancer between ≥60 and 60 years old. Methods：10081 patients diagnosed with endometrial cancer were enrolled from 62 hospitals between 2000 and 2010 in Guangdong province.9437 patients among them with more completely surgical and pathological materials were divided into ≥60 and 60 years old groups. The two groups were comparative analyzed. Results：The mean age at diagnosis in ≥60 years old group and 60 years old group was 65. 5 ± 5. 4and 49. 6 ± 6. 8. There were more obesity,diabetes and hypertension in ≥60 years old group（P〈0. 05）. The ratios of type 2 endometrial cancer,G3,p53 positive,lymph vascular space involvement,deep myometric invasion,and abdominal dropsy cytology were higher in ≥60 years old group（ P〈0. 05）,and PR positive were higher in 60 years old group（ P〈0. 05）. The comparisons about ER positive,cervical invasion and lymphatic metastasis in two groups were no differences（ P〈0. 05）. Conclusions：The elderly patients were characterized with more obesity,diabetes and hypertension,and had poorer prognosis factors.