期刊文献+

卵巢癌预后评估模型的研究进展 被引量:6

下载PDF
导出
摘要 上皮性卵巢癌是严重威胁女性健康的恶性肿瘤,其复发率高、早期诊断率低。与其他恶性肿瘤一样,不同卵巢癌患者在分子水平上存在高度异质性。随着对卵巢癌临床病理特征分析和分子研究的日益成熟,研究者旨在通过制定卵巢癌分子预后评估模型来对患者进行预后评估、指导个体化治疗。其中基于TCGA肿瘤基因研究的浆液性卵巢癌预后分型评估在临床上得到了一定的验证,而其他病理类型和亚型的分子预后评估模型研究还在探索中。在此就卵巢癌预后评估模型的研究重点予以阐述,为提高卵巢癌的治疗疗效提供思考线索。
作者 张梅莹 狄文
出处 《现代妇产科进展》 CSCD 北大核心 2015年第5期375-377,共3页 Progress in Obstetrics and Gynecology
  • 相关文献

参考文献21

  • 1Slomski A. Screening women for ovarian cancer still does more harm than good [ J ]. JAMA, 2012,307 ( 23 ) : 2474- 2475.
  • 2van Houwelingen JC, ten Bokkel Huinink WW, van der Burg ME, et al. Predictability of the survival of patients with advanced ovarian cancer [ J ]. J Clin Oncol, 1989,7 (6) .769-773.
  • 3Clark TG, Stewart ME, Altman DG, et al. A prognostic model for ovarian cancer[ J ]. Br J Cancer,2001,85 (7) : 944-952.
  • 4Gronlund B, Christensen IJ, Bulow-Lehnsby AL, et al. Re- current epithelial ovarian cancer: validation and improve- ment of an established prognostic index [ J ]. Eur J Obstet Gynecol Reprod Biol,2005,123 ( 1 ) :98-106.
  • 5Zang RY, Harter P, Chi DS, et al. Predictors of survival in patients with recurrent ovarian cancer undergoing seconda- ry cytoreductive surgery based on the pooled analysis of an international collaborative cohort [ J ]. Br J Cancer, 2011, 105 (7) : 890-896.
  • 6Bonome T, Levine DA, Shih J, et al. A gene signature pre- dicting for survival in suboptimally debulked patients with ovarian cancer [ J ]. Cancer Res, 2008,68 ( 13 ) : 5478-5486.
  • 7The Cancer Genome Atlas Research Network. Intergrated genomic analyses of ovarian carcinoma[ J]. Nature,2011, 474 (7353) :609-615.
  • 8Verhaak RG, Tamayo P, Yang JY, et al. Prognostically rel- evant gene signatures of high-grade serous ovarian carcino- ma[ J3. J C|in Invest,2013,123 ( 1 ) :517-525.
  • 9Riester M, Wei W, Waldron L, et al. Risk prediction forlate-stage ovarian cancer by Meta-analysis of 1525 patient samples[Jl. J Nati Cancer Inst, 2014, 106(5): pii: dju048.
  • 10Vergote I,Trope CG,Amant F,et al. Neoadjuvant chemo- therapy or primary surgery in stage IIIC or IV ovarian cancer [ J ]. N Engl J Med, 2010,363 ( 10 ) : 943-953.

同被引文献53

引证文献6

二级引证文献36

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部