肿瘤的淋巴管生成和淋巴血管重塑

Lymphangiogenesis and lymphatic vessel remodelling in cancer

肿瘤的转移主要经由淋巴管转移,目前主要围绕淋巴管的转移机制展开研究,希望通过淋巴管的生成及肿瘤淋巴管的重塑机制来阐述肿瘤的淋巴结转移。淋巴结的转移与否直接关系到肿瘤患者的预后以及生存质量,如何通过阻断相应的信号传导通路防止肿瘤的淋巴管生成成为研究的重点,文中主要就淋巴管的生成以及淋巴管重塑进行综述。

It is well known that the tumor mainly transfers through the lymphatic vessels of the tumor. The current studies mainly focus on the mechanism of metastasis,hoping to uncover the lymph node metastasis through investigating generation of lymphatic vessels and remodeling of tumor lymphatic vessels. Lymph node metastasis is directly related to and prognosis and the quality of life of cancer patients,and how to block the corresponding signaling pathways to prevent tumor lymphangiogenesis becomes the research focus. This paper reviews the lymphangiogenesis and lymphatic vessel remodeling.