期刊文献+

温州地区胰腺癌发病危险因素分析 被引量:2

Risk factors for pancreatic cancer in Wenzhou area
原文传递
导出
摘要 目的 探讨温州地区胰腺癌发病的危险因素.方法 以病例对照研究方法对经确诊的220例胰腺癌患者及220例匹配的对照人群进行危险因素的条件Logistic回归分析.结果 单因素Logistic分析显示,体重指数(BMI) >30 kg/m^2、吸烟、生育胎数、糖尿病、胆囊炎、胆石症、慢性胰腺炎、阑尾切除史、胃手术史、恶性肿瘤史、恶性肿瘤家族史、高脂血症等因素为胰腺癌发病的危险因素.多因素Logistic回归分析显示,吸烟(OR=3.624,95%CI1.474 -8.907)、BMI> 30 kg/m^2(OR =1.789,95% CI1.030 -3.108)、糖尿病(OR =3.191,95%CI1.094-9.309)、慢性胰腺炎(OR=4.972,95%CI1.593-14.898)、胆囊炎(OR =2,289,95% CI1.024-5.116)是胰腺癌发病的危险因素.结论 BMI> 30 kg/m^2、吸烟、糖尿病等是温州地区胰腺癌发病的危险因素。 Objective To investigate the risk factors of pancreatic cancer in Wenzhou area.Methods A case control study was conducted on 220 cases with pancreatic cancer and 220 matched controls using conditional logistic regression analysis.Results Univariate analysis showed BMI 〉 30 kg/m^2,smoking,reproductive history,diabetes,cholecystitis,chronic pancreatitis,history of appendectomy,history of partial gastrectomy,history of cancer and familial history of cancer were associated with pancreatic cancer,while multivariate conditional logistic regression analysis showed that the risk factors of pancreatic cancer included smoking (OR =3.624,95% CI i.474 ~ 8.907),BMI 〉 30 kg/m^2 (OR =1.789,95% CI 1.030 ~ 3.108),diabetes (OR =3.191,95% CI 1.094 ~ 9.309),chronic pancreatitis (OR =4.972,95% CI 1.593 ~ 14.898),and cholecystitis (OR =2.289,95 % CI 1.024 ~5.116).Conclusions BMI 〉 30 kg/m2,smoking and diabetes are risk factors for pancreatic cancer in Wenzhou area.
出处 《中华胰腺病杂志》 CAS 2015年第3期173-176,共4页 Chinese Journal of Pancreatology
基金 温州市科技局资助(Y20140289)
关键词 胰腺肿瘤 回归分析 危险因素 LOGISTIC模型 Pancreatic neoplasm Regression analysis Risk factors Logistic models
  • 相关文献

参考文献18

  • 1Lowenfels AB, Maisonneuve P. Epidemiology and preventionof pancreatic cancer[ J ]. Jpn J Clin Oncol, 2004,34 (5) :238-244.
  • 2Michaud DS. Epidemiology of pancreatic cancer [ J ]. Minerva Chir, 2004,59 (2) :99-111.
  • 3Zheng W, Mc Laughlin JK, Gridley G, et al. A cohort study of smoking, alcohol consumption and dietary factorsfor pancreatic cancer( United States) [ J]. Cancer causes control, 1993,4(5 ) : 477-482.
  • 4王俊,高玉堂,王学励,刘恩菊,张玉兰,袁剑敏.上海市区男性吸烟与恶性肿瘤死亡的前瞻性研究[J].中华流行病学杂志,2004,25(10):837-840. 被引量:27
  • 5Hassan MM, Abbruzzese JL, Bondy ML, et al. Passive smoking and the use of noncigarette tobacco products in association with risk for pancreatic cancer: a case-control study [ J]. Cancer, 2007,109(12) :2547-2556.
  • 6周国中,李兆申.胰腺癌1027例临床流行病学研究[J].世界华人消化杂志,2005,13(1):55-60. 被引量:6
  • 7Li D, Firozi PF, Zhang W, et al. DNA adducts, genetic polymorphisms, and K-ras mutation in human pancreatic cancer [ J] . Mutat Res ,2002,513 (1-2) :37-48.
  • 8Lee JH, Kim SA, Park HY. et al. New -onset diabetes patients need pancreatic cancer screening [ J ] .9 J Clin Gastroenterol, 2012, 46(7) : 58-61.
  • 9Pelaez-Luna M, Takahashi N, Fletcher JG, et al. Reseetability of presymptomatic pancreatie cancer and its relationship to onset of diabetes : a retrospeetive review of CT seans and fasting glucose values prior to diagnosis [ J ]. Am J Gastroenterol, 2007, 102 (10) : 2157-2163.
  • 10Larsson SC, Orsini N, Wolk A. Body mass index and pancreatic cancer risk : A meta-analysis of prospeetive studies [ J ]. Int J Cancer,2007, 120(9) : 1993-1998.

二级参考文献47

  • 1Ye W, Lagergren J, Weiderpass E, Nyren O, Adami HO, Ekbom A. Alcohol abuse and the risk of pancreatic cancer. Gut 2002;51:236-239.
  • 2Michaud DS, Giovannucci E, Willett WC, Colditz GA, Fuchs CS. Coffee and alcohol consumption and the risk of pancreatic cancer in two prospective United States cohorts. Cancer Epidemiol Biomarkers Prev 2001;10:429-437.
  • 3Berrington de Gonzalez A, Sweetland S, Spencer E. A metaanalysis of obesity and the risk of pancreatic cancer. Br J Cancer 2003;89:519-523.
  • 4Michaud DS, Giovannucci E, Willett WC, Colditz GA,Stampfer MJ, Fuchs CS. Physical activity, obesity, height, and the risk of pancreatic cancer. JAMA 2001;286:921-929.
  • 5Ghadirian P, Lynch HT, Krewski D. Epidemiology of pancreatic cancer:an overview. Cancer Detect Prev 2003;27:87-93.
  • 6Schernhammer ES, Michaud DS, Leitzmann MF, Giovannucci E, Colditz GA, Fuchs CS. Gallstones, cholecystectomy, and the risk for developing pancreatic cancer. Br J Cancer 2002;86:1081-1084.
  • 7Talamini G, Falconi M, Bassi C, Casetti L, Fantin A, Salvia R, Pederzoli P. Previous cholecystectomy, gastrectomy, and diabetes mellitus are not crucial risk factors for pancreatic cancer in patients with chronic pancreatitis. Pancreas 2001;23:364-367.
  • 8Ye W, Lagergren J, Nyren O, Ekbom A. Risk of pancreatic cancer after cholecystectomy:a cohort study in Sweden. Gut 2001;49:678-681.
  • 9Tascilar M, van Rees BP, Sturm PD, Tytgat GN, Hruban RH,Goodman SN, Giardiello FM, Offerhaus GJ, Tersmette AC .Pancreatic cancer after remote peptic ulcer surgery. J Clin Pathol 2002;55:340-345.
  • 10Kreiger N, Lacroix J, Sloan M. Hormonal factors and pancreatic cancer in women. Ann Epidemiol 2001;11:563-567.

共引文献32

同被引文献22

引证文献2

二级引证文献17

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部