射频消融治疗妇科恶性肿瘤转移性病变

Radiofrequency ablation for metastatic lesions from gynecologic malignancies

目的探讨CT引导下射频消融(RFA)治疗妇科恶性肿瘤转移性病变的局部近期疗效及安全性。方法对13例妇科恶性肿瘤(卵巢癌、子宫内膜癌、宫颈癌)转移癌患者进行CT引导下RFA治疗,包括肝脏转移8例、腹膜后转移1例、盆腔转移3例、颈根部淋巴结转移合并盆腔转移1例。结果经RFA治疗,完全缓解2例(2/13,15.38%);部分缓解7例(7/13,53.85%);病情平稳2例(2/13,15.38%);疾病进展2例(2/13,15.38%)。肿瘤缓解率67.23%(9/13)。不良反应包括一过性发热1例,恶心、呕吐1例,一过性声音嘶哑1例,腰大肌穿刺路径血肿1例;无其他严重并发症发生。结论 RFA治疗妇科恶性肿瘤转移性病变安全、有效。

Objective To investigate the short-term efficacy and safety of radiofrequency ablation（ RFA） for metastatic lesions from gynecologic malignancies. Methods A total of 13 patients with metastatic lesions from gynecologic malignancies（ ovarian,endometrial and cervical cancer） underwent RFA,including liver metastasis（ n = 8）,retroperitoneal metastasis（ n = 1）,pelvic metastasis（ n = 3）and neck lymph node metastasis combined with pelvic metastasis（ n = 1）. Results After RFA treatment,complete response,partial response,stable disease and progressive disease was achieved in 2 cases（ 2 /13,15. 38%）,7 cases（ 7 /13,53. 85%）,2cases（ 2 /13,15. 38%） and 2 cases（ 2 /13,15. 38%）,respectively. Response rate was 67. 23%（ 9 /13）. Mild fever（ n = 1）,nausea and vomiting（ n = 1）,hoarseness（ n = 1）,psoas major hematoma（ n = 1） was observed. There was no severe complications. Conclusion RFA serves as a safe and effective method to treat metastatic lesions from gynecologic malignancies.