镉的生殖毒性与血睾屏障结构和功能的关系

Correlation between reproductive toxicity of cadmium and structure and function of blood-testis barrier

镉是一种主要的重金属污染物,能够通过消化道、呼吸道等途径进入人体并在体内积累,导致多器官损害。其中镉对雄性生殖系统的毒性作用尤为复杂,严重者可导致不育。因此,通过对镉毒性机制的深入探讨,寻找对抗药物的作用靶点,已成为当前该领域研究的热点。该文针对镉对血睾屏障相关连接蛋白的影响以及可能参与其中的信号通路作一综述。

Cadmium （Cd） is a major heavy metal pollutant. It can enter and accumulate in human body by eating and breathing, which cause damages to various organs finally. The toxicity of Cd towards testis is extremely complicated and may result in male infertility. So many studies focus on identifying action targets of drugs by thoroughly investigating the mechanism of toxicity of Gd. This paper reviews the effects of Cd onconnexins relevant to blood-testis barrier and signaling pathways that may involved.