磷酸钙生物陶瓷在骨及软骨组织工程中的应用

Calcium phosphate bioceramic for bone tissue engineering

为修复肿瘤、创伤及病理因素引起的骨缺损,随着纳米和生物技术的发展,一系列新型的骨组织工程支架材料被制备出来。磷酸钙生物陶瓷作为一种可吸收的生物陶瓷,具有良好的骨传导性能、成骨性能及可控降解性能,在骨组织工程中日益被人们所熟知。同时,磷酸钙有较高的生物活性,对成骨细胞的黏附、增殖及分化等起着重要作用,并可以降低环境改变引起的细胞损害,是较为理想的骨替代材料。为了更好地掌握纳米生物材料的优点和指导制备新型的骨组织工程支架材料,本文对作为骨组织工程支架材料之一的磷酸钙生物陶瓷的种类、理化性质、生物活性、细胞支架的骨组织工程等进行综述,并对其研究和发展作出展望。

Propelled by nanotechnology and biotechnology pregress,a series of new bone tissue engineering scaffold materials have been developed to repair bone defects caused by tumors,trauma,and pathological factors. As an absorbable bioceramic,calcium phosphate bioceramic is becoming well known in bone tissue engineering for its good performance in osteoconduction,osteoblastic and controlled biodegradability. Meanwhile,calcium phosphate is featured with high bioactivity,thus plays an important role in the adhesion,proliferation and differentiation of osteoblast. Morever,it can reduce cell damages caused by environmental changes. It can be concluded that calcium phosphate is an ideal bone substitute material. In order to better understand the advantages of nano- biomaterials and provide guidance to the preparation and production of new bone tissue engineering scaffold materials,this manuscript performs a literature review on classifications,physicochemical property and bioactivity of calcium phosphate bioceramics,bone tissue engineering and cartilage tissue engineering of cell scaffold,then conducts an outlook on further research and development in the field.