HMGB2与骨性关节炎相关性的研究进展

Research progress of HMGB2 in osteoarthritis

骨性关节炎(osteoarthrisis,OA)是一种严重危害中老年人健康的慢性进行性骨关节疾病,OA的发生过程中最早出现的是关节软骨浅表层的改变,而在人类关节软骨中HMGB2主要表达在浅表区,并随着年龄的增长其表达量呈逐渐下降趋势。在软骨退行性病变中,HMGB2作为核因子对维持软骨细胞分泌表征和内环境的稳定性起着积极作用。

Osteoarthritis（ OA） is a degenerative joint disease that mainly involves dysfunction of articular chondrocytes. The superficial zone（ SZ） of articular cartilage is critical in maintaining tissue function and homeostasis and represents the site of the earliest changes in osteoarthritis. Nonhistone chromatin protein high- mobility group box（ HMGB） protein 2 is uniquely expressed in the superficial zone（ SZ） of human articular cartilage. The age- related loss of HMGB2 in articular cartilage may be associated with the reduced cellularity,and this contributes to the development of OA.