熄风化湿方治疗腹泻型肠易激综合征的临床观察

Clinical Observation of Xifenghuashi Fang in Treating Diarrhea Type of Irritable Bowel Syndrome

目的观察熄风化湿方治疗腹泻型肠易激综合征(IBS)的疗效。方法共入组病例165例,其中治疗组83例,对照组82例,分别给予熄风化湿方和马来酸曲美布汀口服,疗程4周。观察治疗前后主要症状、中医证候改善情况、血清5-羟色胺水平及治疗结束后3月内的复发率。结果治疗后患者腹痛即泻,泻后痛减的改善程度2组无明显差异(P>0.05);急躁易怒,善叹息、两胁胀满、纳少、泛恶、舌淡胖有齿痕、脉弦细的改善程度治疗组明显优于对照组(P<0.05);中医证候总有效率治疗组优于对照组(P<0.05);血清5-羟色胺下降水平治疗组优于对照组(P<0.01);治疗结束后3月内的复发率治疗组优于对照组(P<0.05)。结论熄风化湿方治疗腹泻型IBS疗效确切。

OBJECTIVE To observe the efficacy of Xifenghuashi Fang in treating diarrhea type of Irritable Bowel Syndrome. METHODS 165 patients were randomly divided into the treatment group（83 patients） and the control group（82 patients） who were all confirmed to be type of Irritable Bowel Syndrome according to the Rome III criteria. The treatment group was treated with Xifenghuashi Fang and the others were treated with Trimebutine maleic acid for 4 weeks. The main symptoms, TCM syndromes, the serum level of serotonin and recurrence rate within 3 months were observed before and after treatment. RE- SULTS There was no significant difference between the two groups with the improvement of diarrhea after abdominal pain and relief of abdominal pain after diarrhea （P〉0.05）, and there were significant improvement of symptoms like irritable emo- tions, vulnerable to sigh, swell in both of ribs, eating less, nausea, pale tongue with teeth marks, small and wiry pulse in the treatment group（P〈0.05）. The total efficiency of TCM syndromes of treatment group was better than control group （P〈0.05）. The decline of serotonin of treatment group was more obvious than control group（P 〈0.01）. The recurrence rate of treatment group was lower than control group too （P 〈0.05）. CONCLUSION Xifenghuashi Fang has a significant effect in treating diarrhea type of Irritable Bowel Syndrome.