育龄妇女泌尿系统大肠埃希菌感染及耐药性分析

Urinary system Escherichia coli infection of women of childbearing age and drug resistance analysis

目的:调查育龄妇女泌尿系统大肠埃希菌的感染现状及对抗生素的耐药性,为临床合理应用抗生素提供参考。方法:对住院育龄妇女泌尿系统标本培养出大肠埃希菌及对抗生素耐药性进行回顾性分析。结果:共分离出大肠埃希菌133株,其中产超广谱β-内酰胺酶(ESBLs)菌株占42.9%。大肠埃希菌对亚胺培南100.0%敏感,对阿米卡星、呋喃妥因及哌拉西林/他唑巴坦的耐药率较低,对其他抗生素的耐药率均高于50.0%,产ESBLs阳性大肠埃希菌对抗生素的耐药率明显高于不产ESBLs菌株。结论:育龄妇女泌尿系统感染大肠埃希菌对常用抗生素耐药现象不容乐观,临床应根据药敏结果合理选用抗生素。

Objective:To investigate urinary system Escherichia coli infection status of women of childbearing age and the re-sistance to antibiotics, in order to provide a basis for clinical rational use of antibiotics therapy. Methods: The urinary system speci-mens of the hospitalized women of childbearing age were used to culture Escherichia coli, and the resistance was retrospectively ana-lyzed. Results:A total of 133 strains of Escherichia coli were isolated, including 42. 9% of strains producing ESBLs. The sensitivity of Escherichia coli to Imipenem was 100. 0%, but the resistance rate to Amikacin, Nitrofurantoin and Piperacillin/Tazobactam was lower. Moreover, the resistance rates to other antibiotics were higher than 50. 0%. The resistance rate to antibiotics of positive Esche-richia coli producing ESBLs was significantly higher than those not producing ESBLs strains. Conclusions: The phenomenon, which the women of childbearing age urinary tract Escherichia coli infection and its resistance to commonly used antibiotics, is not optimistic. It should legitimately use antibiotics according to the results of drug susceptibility in the clinic.