化浊通瘀汤联合辛伐他汀治疗急性脑梗死合并高脂血症100例临床观察

Clinical observation on treating 100 cases of acute cerebral infarction plus hyperlipidemia with the Huazhuo Tongyu decoction plus Simvastatin

目的:观察自拟化浊通瘀汤与辛伐他汀联合治疗对急性脑梗死患者合并高脂血症的临床疗效。方法:将190例该病患者随机分为两组,治疗组100例,应用中药化浊通瘀汤(处方:黄芪、白术、泽泻、山楂、薏米、茵陈、决明子、何首乌、柴胡、郁金、水蛭、川芎、红花、丹参)联合辛伐他汀治疗;对照组90例,常规应用西药辛伐他汀片治疗。两组均治疗4周后复查血脂,统计疗效。结果:两组总有效率比较,治疗组优于对照组,差异有统计学意义(P<0.05);两组治疗后与本组治疗前比较TC、TG、LDL-C均降低(P<0.05),HDL-C升高(P<0.05),且两组治疗后比较,差异均有统计学意义(P<0.05)。结论:自拟化浊通瘀汤与辛伐他汀联合治疗急性脑梗死患者血脂增高者比单用西药降脂效果更好。

Objective: To observe clinical effects of the Huazhuo Tongyu decoction plus Simvastatin on acute cerebral infarction plus hyperlipidemia. Methods: 190 patients were randomly divided into the treatment group(100 cases) and the control group(90 cases). The treatment group received the Huazhuo Tongyu decoction(Prescription: Huangqi, Baizhu, Zexie, Shanzha, Yimi, Yinchen, Juemingzi, Heshouwu, Chaihu, Yujin, Shuizhi, Chuanxiong, Honghua, Danshen) plus simvastatin. The control group received western medicine simvastatin tablets. In 4 weeks, blood fat were reviewed, efficacy was compared. Results: The total efficiency in the treatment group than that in the control group; the difference was statistically significant(P<0.05). Compared with the previous, TC, TG, LDL-C were lower(P<0.05), HDL-C was increased(P<0.05). Conclusion: Compared with simvastatin, the Huazhuo Tongyu decoction plus simvastatin was more effective on acute cerebral infarction plus hyperlipidemia.