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埃博拉病毒与天然免疫 被引量:4

Ebola virus and innate immunity
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摘要 埃博拉病毒(Ebola virus,EBOV)引起的埃博拉病毒病(Ebola virus disease,EVD)是迄今发现的最凶猛的烈性传染病之一。EVD传染性强、死亡率高,目前尚无特效治疗方法。EBOV感染后能够引起机体出现一系列免疫反应,宿主出现特异性及非特异性抗病毒免疫缺陷是EVD致死的重要原因。本文就EBOV对人体天然免疫功能的影响及其相应对策的研究进展作一综述。 Ebola virus disease(EVD)caused by Ebora virus(EBOV)is one of the most violent infectious disease so far.It is so highly infective and fatal that there has been no effective treatment until now.Ebola viral infection can cause a series of immune responses.Specific and nonspecific antiviral innate immune deficiency in the hosts is a recognized important reason for EVD associated death.This paper reviews the influence of EBOV on innate immune reaction of humans and the corresponding countermeasures.
出处 《第二军医大学学报》 CAS CSCD 北大核心 2015年第6期607-611,共5页 Academic Journal of Second Military Medical University
关键词 埃博拉病毒 天然免疫 干扰素类 紧密连接部 树突细胞 细胞因子风暴 Ebola virus natural immunity interferons tight junctions dendritic cells cytokine storm
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  • 1Rosenthal P J,Bausch D G. Perspectives on Ebola [J]. Am Trop Med Hyg,2015,92:219-220.
  • 2World Health Organiztion (WHO) : Ebola virus disease[R]. http://www, who. int/mediacentre {actsheets/ fs103/zh/.
  • 3Wong G, Kobinger G P, Qiu X. Characterization of host immune responses in Ebola virus infections[J]. Expert Rev Clin Immunol, 2014,10 : 781-790.
  • 4饶贤才.埃博拉病毒病之病原学[J].第三军医大学学报,2015,37(4):282-286. 被引量:7
  • 5Li Y H, Chen S P. Evolutionary history of Ebola virus [J]. Epidemiol Infect, 2014,142 : 1138-1145.
  • 6Baize S, Pannetier D, Oestereich L, Rieger T, Koivogui L,Magassouha N,et al. Emergence of Zaire Ebola virus disease in Guinea [J]. N Engl J Med, 2014,371:1418- 1425.
  • 7Olival K J, Hayman D T. Filoviruses in bats: current knowledge and future directions [J]. Viruses, 2014,6: 1759-1788.
  • 8Ktihl A, POhlmann S, How Ebola virus counters the interferon system[J]. Zoonoses Public Health, 2012,59 Suppl 2 : 116-131.
  • 9徐庆强,唐海琳,戚中田.埃博拉病毒的研究进展[J].第二军医大学学报,2015,36(2):188-192. 被引量:5
  • 10Dolnik O, Kolesnikova L, Becker S. Filoviruses: interactions with the host cell[J]. Cell Mol Life Sci, 2008,65 : 756-776.

二级参考文献65

  • 1中华人民共和国国家卫生和计划生育委员会.埃博拉出血热防控方案[EB/OL].[2014-7-31].http://www.moh.gov.cn/jkj/s3578/201407/530a2d22409249a7a5ibde51 f0117b32, shtml.
  • 2Feldmann H, Geisbert T W. Ebola haemorrhagic fever[J] Lancet, 2011, 377: 849-862.
  • 3Sanchez A, Geisbert T W, Feldmann H. Filoviridae, Marburg and Ebola viruses[M]/ /Fields B N, Knipe D M, Howley P M. Fields virology. 5th ed. Philadelphia: Lippincott Williams & Wilkins, 2007 :1410-1448.
  • 4Colebunders R, Borchert M. Ebola haemorrhagic fever-a review[J]J Infect, 2000, 40: 16-20.
  • 5WHO. Ebola haemorrhagic fever in Sudan, 1976. Report of a WHO/Internatianal Study Team[J]. Bull World Health Organ, 1978, 56: 247-270.
  • 6TownerJ S, Sealy T K, Khristova M L, Albarino C G, Conlan S, Reeder S A, et al. Newly discovered ebola virus associated with hemorrhagic fever outbreak in UgandaD]. PLoS Pathog , 2008. 4: e1000212.
  • 7Jahrling P B, Geisbert T W, Dalgard D W,Johnson E D, Ksiazek T G. Hall W C. et al. Preliminary report: isolation of Ebola virus from monkeys imported to USA Towner[J]. Lancet, 1990, 335: 502-505.
  • 8Groseth A. Feldmann H, StrongJ E. The ecology of Ebola virus[J] Trends Microbiol, 2007, 15: 408-416.
  • 9Wilson] A. Bosio C M, Hart M K. Ebola virus: the search for vaccines and treatments[J]. Cell Mol Life Sci. 2001, 5802-13): 1826-124l.
  • 10Feldmann H, W ahl-Jensen V,Jones S M, Strober U. Ebola virus ecology: a continuing mysteryj]]. Trends Microbiol, 2004,12: 433-437.

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