急性百草枯中毒患者血清中淀粉酶和脂肪酶检测的临床意义

Clinical significance of serum amylase and lipase in patients with acute paraquat poisoning

目的 研究急性百草枯中毒（acute paraquat poisoning,APP）患者的血清中淀粉酶（AMY）和脂肪酶（LPS）的指标变化及临床意义.方法 回顾性分析广州市第十二人民医院2014年收治的62例APP患者的临床资料.以住院期间临床死亡作为观察终点,将62例患者分为存活组32例、死亡组30倒.分别采集患者入院第1、3、7天空腹静脉血,进行AMY、LPS的检测,两组数据比较并进行统计学分析.结果 存活组入院第1、3、7天AMY、LPS均明显低于死亡组,差异有统计学意义（P＜0.05）;死亡组入院第3天AMY、LPS较入院第1天明显增高,差异有统计学意义（P＜0.05）;而存活组未见明显变化,差异无统计学意义（P＞0.05）.结论 APP患者血清中AMY和LPS的指标变化与中毒程度有关,是判断病情严重程度及顸后的可靠指标.

Objective To investigate the changes in serum amylase （AMY） and lipase （LPS） and their clinical significance in patients with acute paraquat poisoning （APP）.Methods The clinical data of 62 APP patients who were admitted to Guangzhou 12th People＆#39;s Hospital in 2014 were retrospectively analyzed.With clinical death being regarded as the end point of observation,the 62 patients were divided into survival group （n=32） and death group （n=30）.The fasting venous blood of the patients on the 1st,3rd,and 7th day after admission were collected,and the AMY and LPS levels were determined;the obtained data were compared between the two groups and analyzed statistically.Results The AMY and LPS levels of the survival group on the 1st,3rd,and 7th day after admission were significantly lower than those of the death group （P〈0.05）;the AMY and LPS levels of the death group on the 3rd day were significantly higher than those on the 1st day after admission （P〈0.05）;the survival group demonstrated no significant changes in AMY and LPS levels （P〉0.05）.Conclusion Changes in AMY and LPS levels in APP patients are reliable indicators for the determination of poisoning severity and prognosis.