摘要
KCND/Kv4(Shal)家族成员负责编码电压门控钾通道(Kv4.1,Kv4.2和Kv4.3),这类通道在心脏和神经元中调节自然和快速失活的A型钾电流。该A型钾电流可被隶属于α钾通道毒素第15家族的短链蝎神经毒素特异性地抑制。这类毒素也被称为孔区阻断剂,与调节通道门控特征的蜘蛛毒素的作用模式是不同的。本文综述了α钾通道毒素第15家族的化学及药理学信息。
Voltage-gated potassium channels（Kv4.1, Kv4.2 and Kv4.3） encoded by the members of the KCND/Kv4（Shal） channel family mediate the native, fast inactivating（A-type） K＋ current（IA） described both in heart and neurons. This IA current is specifically blocked by short scorpion toxins that belong to the α-KTx15 subfamily and which act as pore blockers, a different mode of action by comparison to spider toxins known as gating modifiers. This review summarizes our present chemical and pharmacological knowledge on the α-KTx15 toxins.
出处
《生理学报》
CAS
CSCD
北大核心
2015年第3期248-254,共7页
Acta Physiologica Sinica
