男性尿道分离的解脲脲原体药物敏感性分析

Drug resistance analysis in Ureaplasma urealyticum isolated from male urethra

目的:研究男性尿道分泌物解脲脲原体(Uu)对部分常用抗生素的耐药性及其合理选择。方法:采用珠海丽拓支原体鉴定、药敏试剂盒对243例男性尿道感染者进行支原体检测,对Uu阳性标本进行抗生素敏感性测定并指导选择有效抗生素。结果:82例阳性标本中Uu耐药性分析提示喹诺酮类抗生素的耐药率较高,而四环素类抗生素的敏感性较高,经选用敏感抗生素规范治疗后疗效显著。结论:男性尿道Uu的耐药性分析对指导临床抗生素的合理选择具有重要意义。

Objective： To study the drug resistance and rationale for choosing antibiotics for urethral Ureaplasma urealyticum （Uu）. Methods： The Mycoplasma identification and drug sensitivity kit from Zhuhai Li Tuo was used to detect Mycoplasma in 243 males with urethral infections. The Uu positive samples were further tested for sensitivity to antibiotics. Choosing effective antibiotics was based on the results of sensitivity test. Results： Among 82 Uu positive samples, the rate of resistance to quinolones was higher, but they were sensitive to tetracycline. A marked improvement was achieved following treatment with sensitive antibiotics. Conclusion： Drug resistance test is important for clinicians to choose antibiotics for treating male urethral Uu.