CTHRC1在食管鳞癌中的表达及其临床意义

Expression of CTHRC1 and its clinicopathological significance in esophageal squamous cell carcinoma

目的检测CTHRC1在食管鳞癌组织中的表达并分析其临床意义。方法通过组织芯片和免疫组化技术检测215例食管鳞癌组织中CTHRC1蛋白表达,分析其异常表达与临床病理特征以及预后之间的关系。结果 CTHRC1在癌旁鳞状上皮组织中基本不表达,而在食管鳞癌组织中阳性表达率为61.9%(133/215)。CTHRC1表达与食管鳞癌TNM分期(P<0.001)、浸润深度(P=0.006)和淋巴结转移(P=0.002)有关。单因素生存分析显示食管癌CTHRC1阳性表达者预后较CTHRC1阴性表达者差(中位OS:57个月vs.73个月,P=0.016);多因素回归分析显示CTHRC1表达不是食管鳞癌独立的预后因素。结论 CTHRC1在食管鳞癌的发生和发展过程中异常活化和表达,可能是食管癌治疗的潜在靶点之一。

Objective To explore the clinical significance of CTHRC1 in the development of esophageal squamous cell carcinoma （ ESCC） . Methods CTHRC1 expression of 215 ESCC cases were detected by tissue microarray and immunohistochemistry. Results The positive rate of CTHRC1 expression was 61. 9%（ 133/215） in ESCC, while no or weak expression of CTHRC1 was observed in adjacent noncancerous tissues. There was significant correlation between the expression of CTHRC1 and tumor invasion （ P=0. 006） , lymph node metastasis （ P=0. 002） and tumor stage （ P〈0. 001） . KaplanMeier analysis revealed that patients with CTHRC1 positive expression had a shorter survival time than that without CTHRC1 expression （ medican overall survival： 57 months vs. 73 months,P=0. 016） . CTHRC1 expression was’t an independent factor for ESCC according to multivariable regression analysis. Conclusion CTHRC1 was increased with the development and progression of ESCC, indicating CTHRC1 might modulate the development and progression of ESCC.