E-cadherin在胃癌浸润与转移中作用的研究进展

Progression on the roles of E-cadherin in invasion and metastasis of gastric cancer

肿瘤浸润与转移是胃癌的基本特征,也是引起晚期胃癌患者死亡的首要因素。上皮性钙粘蛋白(E-cadherin)在胃癌发生、发展过程中发挥着重要作用,其表达减少或缺失可诱导上皮间充质转化(MET)的发生。深入研究E-cadherin与胃癌的关系将有助于了解胃癌浸润与转移调控机制,从而为胃癌的临床治疗提供新的理论依据。本文就E-cadherin在胃癌浸润与转移中作用的研究进展作一综述。

Invasion and metastasis are the basic characteristic of gastric cancer, and as well as the main cause of death in gastric cancer patients. Epithelial cadherin（ Ecadherin） plays an important role in the oncogenesis and development of gastric cancer. The decreased expression of Ecadherin can induce epithelialmesenchymal transition（EMT）.So it is very significant for the further study on the relationship between Ecadherin and gastric cancer. It may provide a new theoretical basis for the treatment of gastric cancer. In this paper, we review the progression in Ecadherin for the invasion and metastasis of gastric cancer.