奥氮平防治化疗相关性呕吐的研究进展

Progression on prevention and treatment of olanzapine in chemotherapy-induced nausea and vomiting

化疗所致的恶心呕吐(CINV)是化疗最常见的消化道副作用,也是影响患者化疗依从性的重要原因之一。奥氮平作为一种在精神科已被临床广泛应用的非典型抗精神病药物,具有拮抗多种呕吐相关受体作用,近年被越来越多的研究证实可有效地防治化疗所致的恶心呕吐,且不良反应轻微,耐受性良好。本文综述了近年奥氮平防治CINV的临床研究进展。

Chemotherapyinduced nausea and vomiting is the most common gastrointestinal reaction of chemotherapy side effects, and also one of the important influential factors in chemotherapy compliance within tumor patients. Olanzapine is a widelyused atypical antipsychotics in psychiatric clinical pratice, which also has a ability to block many different antiemetic properties ossociated receptors. In recent years, olanzapine has been approved effectively in the prevention and treatment of chemotherapyinduced nausea and vomiting, with little adverse reaction and good tolerance. This paper summarizes the clnical progression on prevention and treatment of olanzapine in chemotherapy induced nausea and vomiting.