甲状腺功能亢进性肝损害患者血清氧化应激产物与白细胞介素-6水平变化及意义

Change and significance of serum oxidative stress and interleukin-6 in patients with hyperthyroidism-induced liver injury

目的探讨甲状腺功能亢进性肝损害患者血清一氧化氮(nitric oxide,NO)、一氧化氮合酶活性(nitric oxide synthetase,NOS)、丙二醛(malondialdehyde,MDA)、超氧化物歧化酶(superoxide dismutase,SOD)、白细胞介素-6(interleukin-6,IL-6)水平变化及其临床意义。方法甲状腺功能亢进患者(甲亢组)、甲状腺功能亢进性肝损害患者(甲亢肝损组)、非甲状腺功能亢进性肝损害患者(非甲亢肝损组)及体检健康者(对照组)各60例,检测4组NO、NOS、MDA、SOD、IL-6水平并进行比较。结果甲亢肝损组MDA[(12.78±4.59)μmol/L]、IL-6[(158.22±50.76)ng/L]水平高于甲亢组[(9.02±3.78)μmol/L、(132.33±48.49)ng/L]、非甲亢肝损组[(10.32±4.67)μmol/L、(149.39±45.02)ng/L]、对照组[(3.84±1.98)μmol/L、(106.49±38.58)ng/L](P<0.05),NO[(51.35±12.58)μmol/L]、NOS[(36.28±5.09)u/mL]、SOD[(76.92±15.22)u/mL]水平低于甲亢组[NO(58.67±12.58)μmol/L、NOS(40.11±7.27)u/mL、SOD(95.31±25.11)u/mL]、非甲亢肝损组[NO(59.48±14.96)μmol/L、NOS(39.42±5.23)u/mL、SOD(90.67±30.61)u/mL]、对照组[NO(67.45±14.48)μmol/L、NOS(47.15±5.48)u/mL、SOD(113.70±31.86)u/mL](P<0.05);甲亢组、非甲亢肝损组MDA、IL-6水平高于对照组,NO、NOS、SOD水平低于对照组(P<0.05);非甲亢肝损组IL-6水平高于甲亢组,SOD水平低于甲亢组(P<0.05)。结论甲状腺功能亢进性患者发生肝损害与机体氧化应激和炎症反应有关。

Objective To study the changes and clinical significance of nitric oxide （NO）, nitric oxide synthetase （NOS）, malondialdehyde （MDA）, superoxide dismutase （SOD） and interleukin-6 （IL-6） in patients with hyperthyroidism-induced liver injury. Methods The levels of NO, NOS, MDA, SOD and IL-6 were detected and compared in 60 patients with hyperthyroidism （hyperthyroidism group）, 60 patients with hyperthyroidism-induced liver injury （hyperthyroidism-induced liver injury group）, 60 patients with liver injury not induced by hyperthyroidism （non- hyperthyroidism-induced liver injury group） and 60 health volunteers （control group）. Results The levels of MDA and IL-6 were higher in hyperthyroidism-induced liver injury group （（12.78±4.59） μmol/L, （158.22±50.76） ng/L） than those in hyperthyroidism group （（9.02 ± 3.78） μmol/L, （132. 33 ± 48.49） ng/L）, non-hyperthyroidism-induced liver injury group （（10.32μ4.67） μmol/L, （149.39±45.02） ng/L） and control group （（3. 844±1. 98） /μmol/L, （106.49± 38.58） ng/L） （P〈0.05）. The levels of NO, NOS and SOD were significantly lower in hyperthyroidism-induced liver injury group （（51.35±12.58） μmol/L, （36.28±5.09） u/mL, （76.92±15.22） u/mL） than those in hyperthyroidism group （（58.67±12.58）μmol/L, （40. 11±7. 27） u/mL, （95. 31±25. 11） u/mL）, non-hyperthyroidism-induced liver injury group （（59.48±14.96） μmol/L, （39.42±5.23） u/mL, （90.67±30. 61） u/mL） and control group （（67.45± 14.48） μmol/L, （47.15±5.48） u/mL, （113.70±31.86） u/mL） （P〈0.05）. MDA and IL-6 levels were higher, and NO, NOS and SOD levels were lower in hyperthyroidism group and non-hyperthyroidism-induced liver injury group than those in control group （P〈0.05）, IL-6 level was higher and SOD level was lower in non-hyperthyroidism-induced liver injury group than those in hyperthyroidism group （P〈0. 05）. Conclusion Oxidative stress and inflammatory reaction are involved in the hyperthyroidism-induced liver injury.