甲状腺功能亢进对稳定性心绞痛患者发生心房颤动的影响

Effect of hyperthyroidism on the incidence of atrial fibrillation in patients with stable angina

目的甲状腺功能亢进对稳定性心绞痛患者发生心房颤动的影响。方法纳入将2012年7月至2014年6月我院收治的稳定性心绞痛患者567例为研究对象,根据患者血浆中TSH水平分成3组,即TSH〈0.55 m IU/L组、0.55～4.78m IU/L组、〉4.78 m IU/L组。比较3组患者的实验室检查结果,并观察不同组别患者的房颤发生率。结果 567例稳定性心绞痛患者中,44例诊断为阵发性或持续性房颤,发生率为7.8%。TSH在0.55～4.78 m IU/L时房颤发生率最低,为6.4%（30/503）;TSH〉4.78 m IU/L时发生率最高,为19.5%（8/41）,而TSH在〈0.55 m IU/L时房颤发生率为17.4%（4/23）,组间比较差异有统计学意义（P=0.001）。甲状腺功能亢进与稳定性心绞痛患者发生房颤存在相关性。结论甲状腺功能亢进与稳定性心绞痛患者房颤的发生相关。

Objective To explore the effect of hyperthyroidism on the incidence of atrial fibrillation in patients with stable angi -na.Methods 567 patients with stable angina from 2012 Jul to 2014 Jun were included in this analysis .All patients with thyroid function test results were divided into 3 groups according to TSH levels：〈0.55 mIU/L、0.55～4.78 mIU/L and 〉4.78 mIU/L.Gen-eral clinical data and related biochemical parameters were analyzed .Results A total of 44 patients were diagnosed with AF （7.8%）. When the concentration of TSH was 0.55～4.78 mIU/L, the atrial fibrillation incidence rate was 6.4% （30/503）, which was the lowest;When the concentration of TSH was above 4.78 mIU/L, the atrial fibrillation incidence rate was 19.5%（8/41）, which was the highest;When the concentration of TSH was below 0.55 mIU/L, the incidence of atrial fibrillation was17 .4%（4/23）, the differ-ence between groups was statistically significant （P=0.001）.There was correlation between Hyperthyroidism and atrial fibrillation in patients with stable angina .Conclusion Our results show that the incidence of AF increases in proportion to TSH level in patients with stable angina .