脑缺血再灌注引起多器官损伤的研究进展

Progress in Understanding the Multiple Organ Injury Induced by Cerebral Ischemia-Reperfusion

急性缺血性脑血管疾病如脑梗死、脑血栓形成等是老年人常见病和多发病,死亡率高。缺血性脑血管疾病患者发病后,可使某些器官功能损伤甚至衰竭,甚至发生多个器官功能损伤、衰竭。各器官功能衰竭加重原有脑部病灶的损伤,并可使机体各器官进一步受累,形成恶性循环,甚至导致死亡。因此开展脑缺血再灌注多器官损伤防治作用的研究,具有重大医学价值和社会意义。该文就脑缺血再灌注引起的心、肺、肝、肾、胃肠、脾等器官损伤和血流动力学变化以及肢体功能障碍等研究进展进行综述,并提出"双向式"的科学研究概念。

Acute ischemic cerebrovascular diseases such as cerebral infarction and cerebral thrombosis are common and frequently-occurring diseases among the aged people with high mortality rate. After the attack of the ischemic cerebrovascular disease, some organ function would damage and fail, and even worse the occurrence of multiple organs function damage and failure. The failure of various organs causes the aggravation of the original brain lesions, further leading to aggravated multiple organs dysfunction with the emergence of a vicious spiral and even death. Accordingly, it is important to study the prevention and treatment of the multiple organ injury induced by cerebral ischemia-reperfusion. This review focused on the research progress in understanding organ injury such as heart, lung, liver, kidney, gastrointestinal tract, spleen and other organs,hemodynamic changes, and dysfunction of extremities induced bycerebral ischemia-reperfusion. A novel concept on cerebral ischemia-reperfusion was also discussed.