摘要
蛇床子素是中药蛇床子的主要药理活性成分之一,具有多种生理、药理作用。蛇床子素在神经系统的药理作用一直是国内外学者的研究热点,其对改善学习记忆、抗衰老、抗脑缺血再灌注损伤以及中枢神经系统退行性疾病等具有显著影响,而其作用机理多与其抗氧化、抑制炎性反应有关。该文将对蛇床子素的药代动力学特点、神经系统药理作用及其机制的研究进展作一综述。
Ostholv is one of the mainly active ingredients from Cnidium monnieri （L.） Cuss.,and has various pharmacological effects. Effects of ostholc on the nervous system have been the research hotspot of scholars at home and abroad. It has significant influence on improving learning and memory, anti-aging, anti-cerebral ischemia reperfusion injury and the treatment of central nervous system degenerative disease, and the mechanism may be related to its oxidation resistance and inhibiting inflammatory reaction. The pharmacokinctics and the effects and mechanisms of osthole on the nervous system were summarized.
出处
《神经药理学报》
2014年第3期57-64,共8页
Acta Neuropharmacologica
基金
国家自然科学基金项目(No.81274005)
河北省自然科学基金项目(No.C2011405014)
河北省教育厅科研项目(No.2010212)
