兰索拉唑联用吗丁啉治疗胃食管反流病的疗效观察

Observation of curative effect by lansoprazole combined with motilium in the treatment of gastroesophageal reflux disease

目的探讨兰索拉唑联用吗丁啉治疗胃食管反流病的临床疗效。方法 198例胃食管反流病患者随机分为观察组与对照组,每组99例,对照组给予兰索拉唑治疗,观察组在对照组基础上加用吗丁啉治疗,对治疗后两组临床症状改善情况与电子胃镜复查黏膜修复情况进行比较分析。结果观察组临床症状改善率为92.93%,对照组临床症状改善率为74.75%,两组比较差异有统计学意义(P<0.05)。复查电子胃镜结果黏膜修复情况,观察组总有效率为91.92%,对照组总有效率为73.74%,两组比较差异有统计学意义(P<0.05)。结论兰索拉唑联用吗丁啉治疗胃食管反流病,效果显著。

Objective To investigate the clinical effect of lansoprazole combined with motilium in the treatment of gastroesophageal reflux disease. Methods A total of 198 patients with gastroesophageal reflux disease were randomly divided into observation group and control group, with 99 cases in each group. The control group received lansoprazole for treatment, while the observation group received additional motilium. Improvement of clinical symptoms and reexamination condition by electronic gastroscope for mucous rehabilitation were comparatively analyzed in the two groups after treatment. Results Improvement rate of clinical symptoms in the observation group was 92.93%, and that of the control group was 74.75%. The difference between the two groups had statistical significance（P〈0.05）. Total effective rate of reexamination condition for mucous rehabilitation was 91.92% in the observation group, and that was 73.74% in the control group. Their difference had statistical significance（P〈0.05）. Conclusion Combination of lansoprazole and motilium provides precise effect in treating gastroesophageal reflux disease.