银杏内酯B注射液治疗动脉粥样硬化性血栓性脑梗死(瘀血阻络证)的临床研究

Clinical Study on the Effect of Ginkalide B Injection on Atherosclerosis Thrombotic Cerebral Infarction (Static Blood Blocking Collaterals Syndrome)

目的探讨银杏内酯B注射液治疗动脉粥样硬化性血栓性脑梗死(瘀血阻络证)患者的临床疗效。方法将60例动脉粥样硬化性血栓性脑梗死(瘀血阻络证)患者随机分为治疗组和对照组,治疗组32例,对照组28例。治疗组给予银杏内酯B注射液40mg,加入0.9%氯化钠注射液250ml内,静脉滴注,每日1次,对照组给予复方丹参注射液40mg,加入0.9%氯化钠注射液250ml内,静脉滴注,每日1次,2组疗程均为2周。治疗前后观察2组患者神经功能缺损程度评分、中医证候疗效、中医证候评分及日常生活活动能力(ADL)评分。结果治疗后,治疗组患者神经功能缺损程度评分和中医证候积分显著低于对照组(P<0.05),总有效率和ADL评分显著高于对照组(P<0.05)。结论银杏内酯B注射液治疗动脉粥样硬化性血栓性脑梗死(瘀血阻络证)具有良好的临床疗效。

Objective To investigate the clinical efficacy of ginkalide B injection in treating patients with atherosclerosis thrombotic cerebral infarction（static blood blocking collaterals syndrome）.Methods 60 patients with atherosclerosis thrombotic cerebral infarction（static blood blocking collaterals syndrome）were randomly divided into treatment group（32cases）and control group（28cases）.The patients of treatment group were treated by ginkalide B injection 40mg/time,one times/d iv.The patients of control group were treated by compound Dansheng injection 40mg/time,one times/d iv.The therapy course lasted for 2weeks.The nerve function damage degree,the clinical efficacy and integral of syndrome of traditional Chinese medicine and ADL were evaluated after 2weeks.Results The nerve function damage degree and the integral of syndrome of traditional Chinese medicine in the treatment group were significantly lower than that of the control group（P〈0.05）.The total efficiency and ADL in the treatment group were significantly higher than that of the control group（P〈0.05）.Conclusion Ginkalide B is effective in treating atherosclerosis thrombotic cerebral infarction（static blood blocking collaterals syndrome）.