烷基-α-D-吡喃甘露糖苷中间体的合成

Syntheses of Alkylα-D-Mannopyranoside Intermediates

烷基-α-D-吡喃甘露糖苷是重要的表面活性剂和抗菌剂.以D-甘露糖为原料,经乙酰化、选择性脱C1位乙酰基、转化成三氯乙酰亚胺酯、与受体偶联和脱保护五步反应立体专一性地合成了八种烷基-α-D-吡喃甘露糖苷中间体,目标化合物的结构经氢谱和质谱分析得到了确证,方法有效并且产率高.

Alkylα-D-mannopyranosides are important non-ionic surfactant and antimicrobial.Alkylα-Dmannopyranosides were stereospecifically synthesized through five consecutive steps including acetylation,selective deacetylation at the C1 position,conversion to trichloroacetimidate and coupling with acceptors.The structure of the target compound was confirmed by the 1 H NMR and MS analysis,the method is effective and practical,and the yield is high.