IL-17、胱抑素C、同型半胱氨酸在帕金森病患者中的表达及意义

Expression of serum IL-17, cystatin C, homocysteine in patients of Parkinson's disease and their clinical significance

目的探讨白细胞介素17(IL-17)、胱抑素C(CysC)、同型半胱氨酸(Hcy)在帕金森病患者中的表达及意义。方法选择2010年1月至2013年12月期间68例帕金森病(PD)患者为观察组。选择健康人群42例为对照组。将68例PD患者按病情进展分为早期20例(H-Y分期<2);中期22例(2≤H-Y分期<3)和晚期26例(H-Y分期≥3)。将68例PD患者分为认知功能障碍组32例(A组)和无认知功能障碍组36例(B组)。统计两组受试者血清IL-17、CysC、Hcy含量,对血清IL-17、CysC、Hcy与年龄、患病年限、H&Y评分、BMI进行相关性分析。结果 A组、B组血清CysC、IL-17、Hcy水平明显高于对照组(P<0.01),且A组血清CysC、IL-17、Hcy水平高于B组(P<0.01);晚期组血清CysC、IL-17、Hcy水平最高(P<0.01),中期组血清CysC、IL-17、Hcy水平均高于早期组(P<0.01);观察组患者血清IL-17、CysC、Hcy水平与患病年限呈正相关(P<0.05),与H-Y分期呈正相关(P<0.05);血清IL-17、CysC、Hcy水平之间均呈正相关(P<0.05)。结论 IL-17、CysC、Hcy与PD的发病及进展密切相关,可反应病情的严重程度,在PD的进展中起一定作用。

Objective To study the expression of serum cystatin C, interleukin-17（IL-17）, homocysteine（Hcy） in patients of Parkinson＇s disease（PD） and their clinical significance. Methods From January 2010 to December 2013, 68 patients of PD were selected as the observation group. Forty-two healthy people were selected as the control group. The 68 PD patients were divided into three stages according to the progress of the disease： early stage group（20 cases, H-Y stage2）, medium stage group（22 cases, 2≤H-Y3）, advanced stage group（26 cases, H-Y≥3）.The 68 PD patients were divided into the cognitive dysfunction group（32 cases, group A） and without cognitive dysfunction group（36 cases, group B）. Serum CysC, IL-17, Hcy contents were detected. The correlation between serum CysC, IL-17, Hcy and age, disease duration, HY score, BMI were analyzed. Results Serum Cys B, IL-17, Hcy levels in group A and group B were significantly higher than those in the control group（P〈0.01）, and these levels were significantly higher in group A than group B（P〈0.01）. Serum CysC, IL-17, Hcy levels in the advanced stage group was the highest（P〈0.01）, followed by medium stage group and then early stage group（P〈0.01）. Serum IL-17, CysC, Hcy levels were positively correlated with disease duration（P〈0.05） and H-Y score（P〈0.05）. There were positive correlations between serum IL-17, CysC, Hcy levels（P〈0.05）. Conclusion IL-17, CysC, Hcy are closely related to the pathogenesis and progress of PD, which can reflect the severity of the disease and play a role in the development of PD.