小儿EB病毒感染性咽炎与肠系膜淋巴结炎的相关性研究

Correlation between pharyngitis with Epstein-Barr virus infection and mesenteric lymphadenitis in children

目的探讨小儿EB病毒感染性咽炎与肠系膜淋巴结炎的关系。方法选择160例同时存在咽炎及消化道症状的患儿为研究对象,检测其EB病毒特异性抗体(EBV-VCA-Ig M)情况,并行腹部超声检查。比较EBV-VCA-Ig M阳性者和阴性者患儿患肠系膜淋巴结炎情况及其淋巴结长径、同切面淋巴结数量及淋巴结内血流情况。结果 160例患儿中,EBV-VCA-Ig M阳性者62例,阴性者98例。阳性者患肠系膜淋巴结炎16例,占25.8%,阴性者7例,占7.1%,阳性者高于阴性者,差异具有统计学意义(P<0.05);EBV-VCA-Ig M阳性者患儿肠系膜淋巴结长径大于阴性者,同切面淋巴结数量多于阴性组,差异均具有统计学意义(P<0.05);两组患儿的淋巴结血流比较差异也有统计学意义(P<0.05)。结论 EB病毒感染性咽炎患儿发生肠系膜淋巴结炎的比例高,超声学表现具有明显改变。

Objective To explore the relationship between pharyngitis with Epstein-Barr virus（EBV） infection and mesenteric lymphadenitis in children. Methods One hundred and sixty children with simultaneous presence of pharyngitis and gastrointestinal symptoms were chosen as the research subjects. EB virus specific antibody（EBV-VCA-Ig M） was detected, and parallel abdominal ultrasonography were performed. Mesenteric lymphadenitis,the long diameter of lymph node, the number of lymph node in the same section, and blood flow of lymph node were compared between EBV-VCA-Ig M positive and negative patients. Results In the 160 cases, there were 62 cases of EBV-VCA-Ig M positive and 98 cases of EBV-VCA-Ig M negative. Sixteen of the EBV-VCA-Ig M positive cases were found with mesenteric lymphadenitis, accounting for 25.8%（16/62）, and 7 of the EBV-VCA-Ig M negative cases were with mesenteric lymphadenitis（7.1%,7/98）, with statistically significant difference（P〈0.05）. The long diameter of lymph node in EBV-VCA-Ig M positive children was greater than that in the negative ones, and the number of lymph node in the same section of EBV-VCA-Ig M positive children was more, with statistically significant difference（P〈0.05）. There were also significant differences in blood flow of lymph node between the two groups（P〈0.05）. Conclusion Children of pharyngitis with EB virus infection have a high proportion of mesenteric lymphadenitis, with significantly changed ultrasonic features.