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乳果糖口服液联合聚乙二醇电解质散进行结肠镜肠道准备效果临床观察 被引量:33

Effect of lactulose oral solution combined with PEG-4000 electrolyte lavage solution on bowel preparation before colonoscopy
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摘要 目的对比乳果糖口服液联合聚乙二醇电解质散与单纯使用聚乙二醇电解质散进行肠道准备效果。方法采用开放式随机对照方式,将121例拟行结肠镜检查者分为试验组61例(服用乳果糖口服液及聚乙二醇电解质散)和对照组60例(单独服用聚乙二醇电解质散)。结果参照波士顿肠道准备评分标准,试验组为(7.07±0.79)分,对照组为(6.18±1.03)分,组间差异有统计学意义(P=0.000)。到达回盲部所用时间:试验组(8.80±1.74)min,对照组(9.22±1.94)min,组间差异无统计学意义(P=0.220)。大肠息肉检出率:试验组22.95%,对照组15.00%,组间差异无统计学意义,但直径≤0.5cm的小息肉发现率试验组明显高于对照组(P=0.038)。试验组及对照组均无明显不良反应。结论乳果糖口服液联合聚乙二醇电解质散进行肠道准备,其疗效优于单纯使用聚乙二醇电解质散,可提高小息肉的检出率,并且其安全性好,未发现明显不良反应。 Objective To compare the effectiveness of lactulose oral solution combined with PEG- 4000 electrolyte lavage solution with PEG-4000 electrolyte lavage solution only in colonoscopy preparation. Methods A total of 121 patients preparing for colonoscopy were randomly divided into two groups: 61 patients in lactulose oral solution combined with PEG-4000 electrolyte lavage solution group (the experimental group = group A), and 60 patients in PEG-4000 electrolyte lavage solution group ( the control group = group B). During the colonoscopy, the endoscopist blindly scored the cleanness of the bowel, and recorded any adverse event to assess the safety. Results According to the Boston bowel preparation scale, the experi- mental group scored 7.07 + 0. 79, and the control group scored 6. 18 + 1.03, which showed significant sig- nificance(P =0. 000). There was no significant difference in the time of accessing rectum between the two groups[ (8. 80 + 1.74)min VS(9. 22 ~ 1.94) min, P =0. 220]. Polyp detection rate in group A was higher than that in group B, with no significant difference (22, 95% VS 15.00%, P 〉 0. 05 ). The small polyp ( ~〈 0. 5 cm)detection rate in group A was higher than that in group B with significant significance( P = 0. 038 ). No adverse event was recorded in either group. Conclusion The bowel preparation with lactulose oral solu- tion combined with PEG-4000 electrolyte lavage solution is more effective than that with PEG-4000 electrolyte lavage solution alone. It will enhance the detection rate of small polyps with no evident adverse reactions.
作者 刘方旭 许乐
出处 《中华消化内镜杂志》 北大核心 2015年第6期375-377,共3页 Chinese Journal of Digestive Endoscopy
关键词 结肠镜检查 肠道准备 乳果糖 聚乙烯二醇类 Colonoscopy Bowl preparation Lactulose Polyethylene Glycols
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