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贲门失弛缓症动物模型的研究进展 被引量：1

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摘要 贲门失弛缓症是一种食管运动障碍性疾病，以食管缺乏蠕动和松弛不良为特征。贲门失弛缓症在西方人群发病率为1—2／10万人。该病病因还不完全清楚，研究表明，分布在食管远侧和食管下端括约肌（lower esophageal sphincter，LES）的抑制性肌间神经丛缺失，尤其是一氧化氮合酶（NOS）阳性神经元和神经纤维的缺失，是导致LES松弛障碍的主要因素旧“。贲门失弛缓症的动物模型研究比较分散，且各有优缺点，本研究对近年来关于该病动物模型制备方法的情况做一综述。
作者 周国建 赵威 张莉莉 王邦茂
机构地区 天津医科大学总医院消化科
出处 《中华消化内镜杂志》 北大核心 2015年第6期419-420,共2页 Chinese Journal of Digestive Endoscopy
关键词 贲门失弛缓症 动物模型 食管运动障碍性疾病 食管下端括约肌 一氧化氮合酶 肌间神经丛 阳性神经元 神经纤维
分类号 R571 [医药卫生—消化系统] R-332 [医药卫生]
  • 相关文献

参考文献15

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二级参考文献13

  • 1[1]Champion JK, Delise N, Hunt T. Myenteric plexus in spastic motility disorders. J Gastrointest Surg, 2001, 5: 514～516.
  • 2[2]De Giorgio R, Di Simone MP, Stanghellini V,Barbara G, Tonini M, Salvioli B, Mattioli S, Corinaldesi R. Esophageal and gastric nitric oxide synthesizing innervation in primary achalasia.Am J Gastroenterol, 1999, 94: 2357～2362.
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  • 10向正国,张忠兵.贲门失弛缓症的病因、病理和发病机制研究进展[J].中华内科杂志,1999,38(7):494-496. 被引量：10

共引文献3

同被引文献4

  • 1Ruffato A,Mattioli S,Lugaresi ML,et al.Long-term results after Heller-Dor operation for oesophageal achalasia[J].Eur J Cardiothorac Surg,2006,29(6):914-919.
  • 2Champion JK,Delise N,Hunt T.Myenteric plexus in spastic motility disorders[J].J Gastrointest Surg,2001,5(5):514-516.
  • 3Watanabe Y,Ando H,Seo T,et al.Attenuated nitrergic inhibetory neurotransmission to interstitial cells of Cajal in the lower esophageal sphincter with esophageal achalasia in children[J].Pediatr Int,2002,44(2):145-148.
  • 4俞亚萍,夏珏,徐燕玲.1例贲门失弛缓症行POEM围手术期的护理[J].内蒙古中医药,2014,33(34):178-178. 被引量：3

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中华消化内镜杂志
2015年 第6期

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