一氧化碳中毒后迟发性脑病与神经免疫的相关性研究

Correlation study on delayed encephalopathy after carbon monoxide poisoning and nerve immunity

目的探讨一氧化碳中毒后迟发性脑病(DEACMP)与神经免疫的相关性。方法应用ELISA法测定30例DEACMP患者(DEACMP组)、27例急性一氧化碳中毒未发生迟发性脑病患者(ACOP组)及28例健康对照者(健康对照组)中血清IL-4、IL-10、IFN-γ、TGF-β1的水平并进行比较。结果 IL-4水平DEACMP组低于及健康对照组(P<0.05),ACOP组低于健康对照组(P<0.05);IL-10水平DEACMP组低于ACOP组(P<0.05),ACOP组高于健康对照组(P<0.05);IFN-γ水平DEACMP组高于ACOP组及健康对照组(均P<0.05),ACOP组高于健康对照组(P<0.05);TGF-β1水平DEACMP组低于ACOP组及健康对照组(均P<0.05),ACOP组高于健康对照组(P<0.05)。结论 DEACMP的发生与神经免疫损伤机制有关。

Objective To explore the relationship between delayed encephalopathy after carbon monoxide poisoning（DEACMP） and neuro-immunology.Methods The serum levels of IL-4、IL-10、interferon-γ（IFN-γ） and transforming growth factor-β1 （ TGF-β1 ） in 30 patients with DEACMP （ DEACMP group ） , 27 patients with acute carbon monoxide poisoning without delayed encephalopathy （ ACOP group ） and 28 healthy controls （ healthy control group） were determined by ELISA .Comparing the results of each group .Results The level of IL-4 in DEACMP was significantly lower than that in healthy control group （ P〈0.05） ;and ACOP group was significantly lower than that in healthy control group （P〈0.05） .The level of IL-10 in DEACMP was significantly lower than that in ACOP group （P〈0.05）;and ACOP group was significantly higher than that in healthy control group （P〈0.05）.The level of IFN-γin DEACMP group was significantly higher than that of ACOP group and healthy control group （all P〈0.05）;and ACOP group was significantly higher than that in healthy control group （ P〈0.05 ） .The level of TGF-β1 in DEACMP group was significantly lower than that of ACOP group and healthy control group （ all P〈0.05 ） ;and ACOP group was significantly higher than that of healthy control group （ P〈0.05） .Conclusion The occurrence of DEACMP is associated with neural immune mechanism of indury .