肿胀性红斑狼疮的研究进展

Progress in lupus erythematosus tumidus

肿胀性红斑狼疮为皮肤型红斑狼疮的亚型之一,其临床特征为紫红色斑,单个或多发斑块,表面光滑,边界清楚,不形成瘢痕,无糜烂、萎缩、鳞屑、毛囊角栓等表皮的改变,且具有显著光敏性,好发于日光暴露部位.组织病理学特点为血管及附属器周围淋巴细胞浸润,真皮网状层黏蛋白沉积,无明显表皮受累,直接免疫荧光检测为阴性.氯喹和羟氯喹治疗有效.

Lupus erythematosus tumidus （LET）,a subtype of cutaneous lupus erythematosus,is clinically characterized by purple patches and single or multiple exudative plaques with smooth surfaces and sharp boundaries which usually occur on sun-exposed areas,and marked photosensitivity without scar formation or epidermal changes such as erosion,atrophy,scaling and follicular plugging.Histopathologically,LET is characterized by lymphocytic infiltration around deep or superficial blood vessels and appendages as well as by mucin deposition in the reticular dermis without obvious epidermal involvement.Direct immunofluorescence （DIF） staining for immunoglobulins is negative.Chloroquine and hydroxychloroquine are effective for the treatment of LET.