维生素D3在2型糖尿病人群中的性别差异被引量：1

Gender Difference in the Serum Levels of Vitamin D3 in Patients with Type 2 Diabetes

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摘要目的了解2型糖尿病患者血清维生素D3水平在不同性别组中的差异.方法按WHO1999年关于糖尿病的诊断标准诊断糖尿病.检查生化指标、甲功和人体参数等.按不同性别分组,比较不同性别组间维生素D3水平与各指标之间的相关性.结果维生素D3与性别、糖尿病病程、T3、FT3、吸烟史呈正相关(P<0.05),男性2型糖尿病组中维生素D3与FT3有相关性(P<0.05),女性2型糖尿病组中维生素D3与T3有相关性(P<0.01).结论维生素D3水平2型糖尿病代谢指标中存在性别差异. Objective To study the gender differences of serum vitamin D3 level in patients with type 2diabetes mellitus.Methods According to WHO1999 year on diabetes diagnosis standard of diabetes. The biochemical indexes of thyroid function and the parameters of the human body, etc. were detected. The correlation of the serum vitamin D3 level in patients with different gender and each index was analyzed. Results Vit D3 was associated with gender, duration of diabetes, T3, FT3, smoking history was, in men with type 2 diabetes mellitus in the group of Vit D3 was correlated with FT3, there was a correlation between type 2 diabetic women with T3.Conclusion Serum vitamin D3 level in patients with type 2 diabetes mellitus has gender difference.

作者梁赟韩文菊

机构地区云南省第一人民医院内分泌科云南省德宏州芒市人民医院内二科

出处《昆明医科大学学报》 CAS 2015年第8期57-60,共4页 Journal of Kunming Medical University

基金云南省卫生科技计划基金资助项目(2010NS010)

关键词 2型糖尿病维生素D3 性别 Type 2 diabetes Vitamin D3 Gender

分类号 R587.1 [医药卫生—内分泌]

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1YANG W,H J, WENTG J,et al. Prevalence of diabetes a-mong men and women in China [J]. N Engl J Med,2010,362(12):1 090-1 101.
2MLLLRTILLS D,WOLFM,PAN D,et al. Prevalence of c-ardiovascular risk factors and the senimm levels of25 -hydroxyvitamin D in the united states : data from thethird national health and nutrition [j ]. Examination SurveyArch Intern Med, 2007,167( 11) : 1 159 - 1 165.
3DENIMAL D,DUGROS V,DUPR T,et al. Agreement ofseven 25-hydroxy vitamin D3 immunoassays and three highperformance liquid chromatography methods with liquidchromatography tandem mass spectrometry [j ], Clin CKemLabMed,2013,24(4):1-10.
4MARTINS-COSTA P,MARTINS H,BRAVO F,et al. C-omparison of automated methods for measurement of25 -hydroxyvitamin D [J]. Clin Lab,2013,59 (7-8):885-891.
5CHIANG K C,CHEN S C,YEH C N,et al. MART -10,aless calcemic vitamin D analog, is more potent than 1 a,25 - dihydroxyvitamin D <sub >3 </sub > in inhibiting themetastatic potential of MCF-7 breast cancer cells in vitro[J]. J Steroid Biochem Mol Biol,2013,139(9) :54-60.
6朱丽颖,宁光.维生素D与2型糖尿病研究进展[J].中国实用内科杂志,2012,32(8):635-637. 被引量：23
7CHAKHTOURS M,AZAT S T.The role of vitamin d defi-ciency in the incidence .progression ,and complication oftype 1 diabetes meilitus [J]. Int J Endocrinol,2013,14(8):673-675.
8CHAGES C E,BORGES M C,MARTINI LA,etal. Focuson vitmine D,infarmmation and type 2 dialbet [j]. Nutri-ent,2012,4( 1 ):52-57.
9MATTILA C, KNEKT P,MANNIST S,et al.Serum 25-hy-oxyvitmin D concentration and subsequent risk Of type 2diabetes [ j] . Diabetes Care, 2007,30 ( 10):2 569 -2570.
10LUO C,WONG J,BROWN M.et al. Hypovitminosis D inChinese type 2 diabetes;lack Of impact On clinicalmetabolic status and biomarkers of cellular inflanmultion[J]. Diab Vase Dis Res,2009,6(3):194-199.

二级参考文献18

1Hidayat R,Setiati S,Soewondo P,et al. The association between vitamin D deficiency and type 2 diabetes mellitus in elderly patients [J].Acta Med Indones,2010,42(3) : 123 - 129.
2Liana C, Gobbo D, Song YQ, et al. Serum 25-hydroxyvitamin D is not associated with insulin resisitance of beta cell function in Canadian Cree [ J].J Nutr,2011,141 (2) :290 -295.
3Liu J, Tan H, Jeynes B. Serum 25 ( OH) vitamin D level, femur length,and risk of type 2 diabetes among adults [ J].Appl Physiol Nutr Metab,2011,36(2) :264 - 270.
4Forouhi NG,Luan J,Cooper A,et al. Baseline serum 25-hydroxy vitamin D is predictive of future glycemic status and insulin resistance :the Medical Research Council Ely Prospective Study 1990— 2000[ J].Diabetes,2008,57(10) :2619 -2625.
5Nikooyeh B, Neyestani TR, Farovid M, et al. Daily consumption of vitamin D - or vitamin D + calcium-fortified yogurt drink improved glycemic control in patients with type 2 diabetes : a randomized clinical trial[J].Am J Clin Nutr,2011,93(4) :764 -771.
6Grimnes G, Emaus N, Joakimsen RM, et al. Baseline serum 25-hydroxyvitamin D concentrations in the Troms? Study 1994—1995 and risk of developing type 2 diabetes mellitus during 11 years of follow-up[J].Diabet Med,2010,27( 10) :1107 -1115.
7Kayaniyil S,Retnakaran R,Harris SB. Prospective associations of vitamin D with beta-cell function and glycemia : the PROspective Metabolism and ISlet cell Evaluation ( PROMISE ) cohort study [ J ].Diabetes,2011,60(11) :2947 -2953.
8Brenner DR,Arora P,Garcia-Bailo B,et al. Plasma vitamin D levels and risk of metabolic syndrome in Canadians[ J].Clin Invest Med, 2011,34(6) :E377.
9Thorand B,Zierer A,Huth C,et al. Effect of serum 25-hydroxyvita-min D on risk for type 2 diabetes may be partially mediated by sub-clinical inflammation : results from the MONICA/KORA Augsburg study [J].Diabetes Care,2011,34( 10) :2320 -2322.
10Geller JL,Hu B,Reed S,et al. Increase in bone mass after correction of vitamin D insufficiency in bisphosphonate-treated patients [J].Endocr Pract ,2008 ,14 (3) :293 -297.