期刊文献+

西非埃博拉病毒病治疗现状 被引量:3

Therapeutic update of Ebola virus disease in west Africa
下载PDF
导出
摘要 埃博拉病毒病传染性强,病死率高,目前尚无疫苗和特异性药物。现将解放军援塞医疗队塞拉利昂埃博拉留观治疗中心的治疗经验进行总结,并结合文献报道,对一些试验性药物的使用情况及临床试验开展情况进行综述,以期为今后应对该疾病提供依据。 Ebola virus disease(EVD) has high infectivity and high mortality. There are no vaccines or antiviral drugs available for EVD. The therapeutic experience obtained by the medical aid team of Chinese PLA working in a holding and treatment center in Freetown, Sierra Leone was summarized, and the use of several experimental drugs and the development of clinical trials were reviewed as well based on some literatures and evidences in hope of providing reference for addressing EVD.
出处 《传染病信息》 2015年第3期129-132,共4页 Infectious Disease Information
关键词 埃博拉病毒属 流行病学 治疗学 Ebolavirus epidemiology therapeutics
  • 相关文献

参考文献14

  • 1WHO.埃博拉病毒病[EB/OL].[2014-08-18].http://www.who.int/mediacentre/factsheets/fs103/zh/.
  • 2埃博拉出血热防控方案(第二版)[J].传染病信息,2014,27(4). 被引量:16
  • 3Bah EI, Lamah MC, Fletcher T, et al. Clinical presentation of pa?tients with Ebola virus disease in Conakry, Guinea[J]. N Engl J Med, 2015, 372(1):40-47.
  • 4Schieffelin JS, Shaffer JG, Goba A, et al. Clinical illness and out?comes in patients with Ebola in Sierra Leone U J. N Engl J Med, 2014,371(22):2092-2100.
  • 5Kreuels B, Wichmann D, Emmerich P, et al. A case of severe Ebo?la virus infection complicated by gram-negative septicemia[J]. N Engl J Med, 2014, 371(25):2394-2401.
  • 6Ekins S, Freundlich JS, Coffee M. A common feature pharma+ cophore for FDA-approved drugs inhibiting the Ebola virus[EBI or.I[2015-04-01]. (http;/lwww.ncbi.nlm.nih.gov/pubmedl?term= A +common+feature+pharmacophore+for+FDA =approved+drugs+in= hibiting+the+Ebola+virus.).
  • 7Wolf T, Kann G, Becker S, et al. Severe Ebola virus disease with vascular leakage and multi organ failure: treatment of a patient in intensive care[J]. Lancet, 2015, 385(9976):1428-1435.
  • 8Forbes. Chimerix ends hrincidofovir Ebola trials to focus on aden?ovirus and CMV[EB/OL].[2015-04-01 J. http://www.forbes.coml sites/davidkro1ll2015/01l311chimerix +ends -brincidofovir -ebola?trials-to-focus-on-adenovirus-and-cmv/.
  • 9Oestereich L, LUdtke A, Wurr S, et al. Successful treatment of ad?vanced Ebola virus infection with T -705 (favipiravir) in a small animal model[J]. Antiviral Res, 2014, 105:17-21.
  • 10Medecins Sans Frontiers. Preliminary results of the JIKI clinical trial to test the efficacy of favipiravir in reducing mortality in indi?viduas infected by Ebola virus in Guinea[EB/OL].[2015-04- 01]. http://www.msf.orglarticle/preliminary -results -jiki -clinical?trial-test-efficacy-favipiravir-reducing-mortality.

共引文献17

同被引文献35

  • 1Towner JS, Sealy TK, Khristova ML, et al. Newly discovered ebola virus associated with hemorrhagic fever outbreak in Uganda [J] . PLoS Pathog, 2008, 4(11):e1000212.
  • 2Report of an International Commission. Ebola haemorrhagic feverin Zaire, 1976 ['J]. Bull World Health Organ, 1978, 56(2):271-293.
  • 3Okware SI, Omaswa FG, Zaramba S, et al. An outbreak of Ebola in Uganda [J] . Trop Med Int Health, 2002, 7(12):1068-1075.
  • 4World Health Organization. Ebola situation report-18 november 2015 [EB/OL] . 1-2015-11-193 . http://apps.who.int/ebola/ eurrent-situation/ebola-situation-report- 18-november-2015.
  • 5World Health Organization. Clinical management of patients with viral haemorrhagic: fever A pocket guide for the front-line health worker [EB/OL7 . [2015-11-19] . http://apps.who.int/iris/ bitstream/10665/130883/2/WHO_HSE_PED_AIP_14.05.pdf.
  • 6World Health Organization. Manual for the care and management of patients in Ebola Care Units/Community Care Centres: interim emergency guidance [EB/OL] . [2015-11-19] http://apps. who.int/iris/bitstream/l O665/149781/ l/WHO_EVD-Manual- ECU 15.1_eng.pdf ua= 1.
  • 7Bwaka MA, Bonnet M J, Calain P, et al. Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo: clinical observations in 103 patients [J] . J Infect Dis, 1999, 179(Suppl 1):S1-$7.
  • 8Schieffelin JS, Shaffer JG, Goba A, et al. Clinical illness and outcomes in patients with Ebola in Sierra Leone [J] . N Engl J Med, 2014, 371(22):2092-2100.
  • 9Dallatomasina S, Crestani R, Sylvester Squire J, et al. Ebola outbreak in rural West Africa: epidemiology, clinical features and outcomes [J] . Trop Med Int Health, 2015, 20(4):448-454.
  • 10Ansumana R, Jacobsen KH, Sahr F, et al. Ebola in Freetown area, Sierra Leone-a case study of 581 patients [J] . N Engl J Med, 2015, 372(6):587-588.

引证文献3

二级引证文献28

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部