性病门诊单纯疱疹病毒2型特异性抗体血清学调查

Herpes simplex virus type 2-specific serology in a sexually transmitted diseases clinic

目的了解性病门诊患者单纯疱疹病毒2型（herpes simplex virus type 2,HSV-2）感染情况。方法用ELISA法检测我院性病门诊1215例患者HSV-2型特异性抗体,并对不同性别和不同年龄组的HSV-2 Ig g G抗体阳性情况进行对比研究。结果 1215例患者中,HSV-2 Ig g G抗体阳性者共291例,阳性率为23.95%,男性阳性率为21.34%（197/923）,女性阳性率为32.19%（94/292）,女性阳性率高于男性,二者比较差异有统计学意义（P〈0.05）。年龄以31~40岁最多,为119例（男性81例,女性38例）;其次为21~30岁,为85例（男性54例,女性31例）。结论 HSV-2型特异性抗体检测率存在男女差异,女性高于男性。生殖器疱疹易发于21~40岁性活跃人群。HSV-2型特异性抗体血清学检测具有快速、简便、灵敏度高等优点,适用于临床检测。

Objective To investigate the prevalence of herpes simplex virus type 2（HSV-2） in the patients visiting a sexually transmitted diseases（STD） clinic. Methods HSV-2-specific antibodies were detected by ELISA method in 1215 patients visiting STD clinic of our hospital, and the HSV- 2 Ig g G positivity of different genders and different age groups were compared and dis-cussed. Results Of 1215 patients, HSV-2 Ig g G antibody positivity was found in 291 patients（23.95%）. The positive rate of the male patients was 21.34%（197/923）, lower than that of the female patients（32.19%, 94/292）, and the difference between the males and the females was significant（P〈0.05）. The patients aged 31-40 years old accounted for the largest proportion（81 males and 38 females）, and followed by the patients aged 21-30 years old（54 males and 31 females）. Conclusions There is significant difference in HSV-2 Ig g G positivity between males and females, and females＇ positive rate is higher than males＇. Genital herpes is liable to occur in patients aged21-40 years old, who are sexually active. Type specific serology test is a rapid, easy and sensitive assay to detect HSV-2, and it can be applied for clinical diagnosis.