血清OPG对PCI术后预后的预测价值

The Predictive Value of Serum Osteoprotegerin for the Prognosis in Patients after PCI

探讨血清骨保护素(OPG)对冠脉介入术(PCI)患者预后的预测价值。选择2011年2月至2013年12月河北医科大学第三医院心内科行PCI的老年冠心病患者125例。检测不同时刻血清OPG水平(PCI术前、术后即刻、术后24小时、术后48小时、术后72小时,以及术后1个月、术后3个月、术后6个月,共8个时间点),记录术后6个月内心血管事件及支架内再狭窄情况。OPG水平和支架内再狭窄高度相关(OR=2.02,P<0.05)。OPG水平高者的心血管事件发生率大。血清OPG水平对PCI术后6个月的心血管事件和支架内再狭窄有较好的预测价值。

To explore the value of osteoprotegerin （OPG ） in prediction of cardiovascular events and restenosis of elderly coronary heart disease patients after percutaneous coronary intervention （PCI） from February 2011 to December 2013 in the Third Affiliated Hospital of Hebei Medical University .Serum OPG concentration of 125 individuals who underwent PCI was evaluated at different time ,including PCI preoperative ,postoperative immediately ,24h ,48h ,72h ,1 month ,3 months and 6 months after operation ,a total of 8 points .Cardiovascular events and ISR were recorded in 6 months after stenting by coronary angiograms .The results showed baseline OPG serum concentration ,measured before PCI ,was higher in ISR patients than those without ISR .The patients with higher OPG values were more susceptible to develop ISR （odd ratio ,2 .02;P〈0 .05） and at high risk for cardiovascular events .OPG serum level may be used as a clinically useful predictor for prognosis of elderly patients after PCI .