肠道菌群与肿瘤的防治

The Relationship between the Gut Microbiota and the Prevention and Treatment of Tumor

人体肠道微生物菌群是一个极其复杂的微生态系统,经过长期的协同进化,肠道菌群与宿主间形成了密切的共生关系,保持肠道菌群平衡对人体健康至关重要。肿瘤是由机体中局部组织的细胞失控导致异常增生与分化而形成的。肿瘤会破坏正常组织与器官,尤其是恶性肿瘤。肠道菌群能够通过激活抗肿瘤细胞因子、调节肠道环境、维持基因组稳定等途径抑制肿瘤的发生与发展,完整的肠道菌群有利于抗癌药物药效的发挥,肠道细菌在肿瘤治疗领域的应用日渐广泛。

The microbiota in the human gut is an extremely complex community ,after a long‐term coevolution .The bacteria and their hosts have a close symbiosis ,and to maintain a well‐balanced intestinal flora is vitally important to human health . A tumor , arises from abnormal grow th and differentiation of body cells , is harmful to normal tissues and organs . Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis ,compared to benign neoplasms . Gut microbiota can inhibit the occurrence and development of the tumor by activating anti‐tumor cytokines ,regulating the gut environment ,maintaining genomic stability and so on ,and they are able to improve the therapeutic efficacy of the anti‐tumor drugs and they have been increasingly used in the tumor treatment .