复方丹参注射液联合尼莫地平治疗血管性痴呆疗效及对患者炎症因子的影响

Curative efficacy of comound danshen injection combination with nimodiine in antients with vascular dementia and its effect on inflammatory factors

目的:探讨复方丹参注射液联合尼莫地平治疗血管性痴呆(vascular dementia,VD)的疗效及对患者炎症因子的影响。方法:将100例VD患者分为对照组45例给予尼莫地平治疗;治疗组55例在对照组的基础上联合使用复方丹参注射液治疗。比较两组患者疗效、MMSE评分、ADL评分及炎症因子水平。结果:治疗后,治疗组MMSE评分、ADL评分、CR与IL-6水平较对照组改善更为显著,差异均具有统计学意义。结论:复方丹参注射液联合尼莫地平治疗VD疗效可靠,可以提高治疗有效率,改善认知功能和日常生活能力,并减轻炎症反应,值得临床进一步研究应用。

Objective：To observe the curative efficacy of comound danshen injection nimodiine in vascular dementia（VD）and its effect on inflammatory factors.Methods：100cases of VD were randomly diveded into two groups.The control group was nimodiine,and the group was combined danshen injection and nimodiin.Clinical effects,MMSE score,ADL score and levels of inflammatory factors were compared.Results：The group had a theraeutic efficiency ratio of 96.4% which was statistically higher than that of 80.0%in the control group（P？0.05）.The MMSE score,ADL score and levels of inflammatory factors the group were better imroved after treatment.Conclusion：Danshen injection nimodiine VD reliable,which increase the effective rate,imrove cognitive function,activity of daily living and relieve inflammatory reaction.