海口地区0～12岁儿童维生素D水平调查研究

Haikou city children aged 0～12 vitamin D levels research

目的了解海口市0-12岁儿童体内维生素D的营养状况,为本地区儿童合理补充维生素D提供科学依据。方法选取0-12岁海口市健康儿童2755例,将其按年龄分婴儿组（〈1岁,共830例）、幼儿组（〉1-3岁,共725例）、学龄前组（〉3-6岁,共515例）、学龄组（〉6-12岁,共685例）。采用罗氏公司cobas e 411化学发光分析仪及配套检测试剂盒检测血清25-（OH）Vit D水平,对结果进行统计分析。结果 2755例儿童25-（OH）Vit D浓度平均值为（30.10±11.61）ng/ml。不同年龄组儿童25-（OH）Vit D浓度平均值比较,差异无统计学意义。婴儿组缺乏率9.28%,幼儿组缺乏率37.10%,学龄前组缺乏率52.04%,学龄组缺乏率68.03%,两两比较缺乏率,差异有统计学意义（P〈0.01）。婴儿组男、女童25-（OH）Vit D浓度平均值比较无差异,但缺乏率比较差异有统计学意义（P〈0.05）,其它各组男女童25-（OH）Vit D浓度平均值和缺乏率比较无差异。血清25-（OH）Vit D浓度平均值夏〉秋〉春〉冬,但差异无统计学意义。结论海口市0-12岁儿童普遍存在维生素D缺乏或不足。特别是学龄前组（〉3-6岁）和学龄组（〉6-12岁）儿童,应采用有效的措施防治维生素D的缺乏,减少维生素D缺乏对儿童健康的影响。

Objective：Understanding Haikou 0-12 years old children′s nutritional status of vitamin D,for the region will provide a scientific basis for reasonable vitamin D supplements. Methods：From haikou city healthy children aged 0-12 2755 cases,the points infant groups according to age（ 〈1 year old,a total of 830 cases）,young children group（ 〉1-3 years old,a total of 725 cases）,the preschool group（ 〉3-6 years old,a total of 515 cases）,the school group（ 〉6-12 years old,a total of 685 cases）. Using roche cobas e 411 chemiluminescence analyzer and form a complete set of detection kit to detect serum 25（OH）Vit D levels,the results were analyzed. Results：2755 cases of children′s average of 25-（OH）Vit D concentration（30.10 ± 11.61 ng/ml. Different age groups of children 25-（OH）average Vit D concentration,there was no statistically significant difference. Baby group lack rate 9.28%,children lack rate 37.10%,lack of preschool group rate is 52.04%,school age groups lack rate is 68.03%,the relative lack of two rate,the difference was statistically significant（P〈0.01）. Male infant group,girls 25（OH）Vit D average concentration is no difference,but the lack of rate difference was statistically significant（P〈0.05）,and other private 25-（OH）groups in terms of Vit D average concentration and lack of rate is no difference. The average concentration of serum 25（OH）Vit D summer 〉autumn 〉spring〉 winter,but there was no statistically significant difference. Conclusion：Haikou city children aged 0-12 widespread vitamin D deficiency or inadequate. Especially group（ 〉3-6 years old）of preschool and school-age group（ 〉6-12 years old）,children should adopt effective measures to prevent and control the lack of vitamin D,reduce the influence of vitamin D deficiency on children′s health.