RNA编辑在肿瘤中的研究进展

Progression of RNA editing in tumor research

RNA编辑参与转录后RNA的调控,已证明与多种肿瘤发生发展相关,现逐渐成为肿瘤领域研究的热点。总结发现RNA编辑主要通过作用于致瘤相关基因(如抑癌基因、致癌基因)转录后RNA来发挥其相应作用。随着RNA编辑在肿瘤中的研究深入,可进一步从转录后水平阐明肿瘤发生发展的潜在机制,为肿瘤诊治提供新的思路。

RNA editing is involved in the regulation of post-transcriptional RNA, which is uncovered to be associated with the growth and progression of many cancers, becoming a hot spot of tumor research. It is concluded that RNA editing contributed to the tumorigenesis process mainly by working on the tumor-related genes, such as cancer suppressor genes and oncogenes. As the research of RNA editing in tumor continues, the underlying mechanisms may be further elucidated at the post-transcriptional RNA level, providing a new theoretical basis for tumor diagnosis and therapy.