酒依赖患者血清同型半胱氨酸与认知功能的关系研究

Relationship between serum homocysteine and cognitive function in alcohol dependence patients

目的探讨酒依赖患者同型半胱氨酸(Hcy)水平与认知功能的关系。方法采用高效液相色谱法测定48例男性酒依赖患者(酒依赖病例组)和40例男性健康对照者(健康对照组)的空腹血清Hcy水平,采用事件相关电位(ERP)方法测定酒依赖病例组和健康对照组的认知功能。结果与健康对照组比较,酒依赖病例组Hcy水平增加,差异有统计学意义(P<0.05),与健康对照组比较,酒依赖病例组ERP测定成分中N2潜伏期(PL)、P3 PL延长,P3波幅(AMP)降低,差异有统计学意义(P<0.05)。酒依赖病例组Hcy水平与N2 PL、P3 PL呈正相关,与P3 AMP呈负相关。结论酒依赖患者Hcy水平明显升高且与认知损伤有关。

[Objective] To explore the relationship between homoeysteine （Hcy） and cognition function in alcohol dependence patients. [Methods] The levels of Hcy in 48 male alcohol-dependent patients （alcohol dependence group） and 40 male healthy adults （healthy control group） were measured by reverse-phase high performance liquid chromatography. The cognitive function of the two groups was detected by event-related potentials （ERP）. [Results] The Hcy level of the alcohol dependence group was higher than that of the healthy control group （P 〈 0.05）. Compared with the N2 period latency （PL） and P3 PL of the healthy control group, those of the alcohol dependence group were higher （P〈 0.05）. Compared with the healthy control group, the P3 amplitude （AMP） was lower in the alcohol dependence group （P 〈 0.05）. In the alcohol dependence group, the Hcy level was positively correlated with N2 PL and P3 PL, but negatively correlated with P3 AMP. [Conclusions] Serum Hcy level obviously increases in the alcohol dependence patients and is correlated with the cognitive dysfunction.