奥卡西平对儿童良性癫痫伴中央颞区棘波脑电图和认知功能的影响

Effect of oxcarbazepine on benign epilepsy combined with centro-temporal spikes and cognitive function

目的观察奥卡西平对儿童良性癫痫伴中央颞区棘波（BECT）脑电图及认知功能的影响。方法选取2011年1月-2013年12月来该院就诊的160例BECT患者，随机分为两组，对照组72例使用卡马西平进行治疗，实验组88例使用奥卡西平进行治疗。治疗后1个月、3个月、6个月、12个月评估患者治疗效果，比较两组患者脑电图和认知功能的差异。结果实验组与对照组相比，无发作、有效、无效水平差异无统计学意义（P〉0．05）；实验组操作智商（PIQ）指标第12个月，语言智商（VIQ）指标第6个月、12个月，短时间记忆第12个月所得值与治疗前比较，差异有统计学意义（P〈0．05），对照组短时间记忆指标第12个月时所得值与治疗前相比差异有统计学意义（P〈0．05）；实验组第6个月的ViQ指标，第12个月的短时间记忆指标优于对照组，差异具有统计学意义（P〈0．05），脑电图指标分析发现，两组患者接受治疗后1个月、3个月内无效水平所占比例最大，6个月、12个月时有效水平所占比例最大。在显效水平中6个月、12个月时两组间差异均具有统计学意义（P〈O．05），在有效水平中1个月、3个月、6个月、12个月两组间差异均具有统计学意义（P〈O．05）。结论奥卡西平对治疗BECT具有很好的疗效，能够提高患者认知功能，其有效性、安全性较好，在临床用药中值得推广。

Objective To observe the effect of oxcarbazepine on benign epilepsy combined with centro-temporal spikes （BECT） and cognitive function. Methods One hundred and sixty patients with BECT were selected from January 2011 to December 2013 and randomly divided into two groups ： 72 patients in control group were treated with carbamazepine, while 88 patients in experimental group were treated with oxcarbazepine. The curative effects were evaluated at 1, 3, 6, and 12 months after treatment; the differences of electroencephalogram （EEG） and cognitive function between the two groups were compared. Results There was no statistically significant difference in onset and effectiveness between the two groups （P〉 0. 05 ）; there were statistically significant differences in performance intelligence quotient （PIQ） on the twelfth month, verbal intelligence quotient （VIQ） on the sixth and the twelfth months, short- term memory value on the twelfth month in experimental group between before and after treatment （ P 〈 0. 05 ） ; in control group, there was statistically significant difference in short-term memory value on the twelfth month between before and after treatment （ P〈0. 05 ） ; VIQ on the sixth month and short-term memory value on the twelfth month in experimental group were statistically significantly higher than those in control group （P〈0. 05） ; ECG showed that the ineffective rates on the first and the third months after treatment in the two groups were the highest, the effective rates on the sixth and the twelfth months were the highest. There were statistically significant differences in the excellent effective rates on the sixth and the twelfth months between the two groups （ P〈0. 05 ）, there were statistically significant differences in the effective rates on the first, the third, the sixth, and the twelfth months between the two groups （P〈0. 05 ） . Condusion The curative effect of oxcarbazepine is good in treatment of BECT, oxcarbazepine can improve cognitive function of the patients, the effectiveness and safety are good, which is worthy of clinical application.