血清维生素D缺乏与多囊卵巢综合征的关联研究被引量：17

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摘要目的分析多囊卵巢综合征(PCOS)妇女血清维生素D水平的情况,为PCOS妇女维生素D补充和风险监测提供指导依据。方法采用病例对照研究,收集150名PCOS患者(PCOS组)和150名健康育龄妇女(对照组)的病历资料,计算体重指数(BMI),测定血清雌二醇(E2)、黄体生成素(LH)、促卵泡雌激素(FSH)、睾酮(T)、空腹血糖(FPG)、空腹胰岛素、总胆固醇(TC)、甘油三酯(TG)及25-(OH)VD3水平,并计算胰岛素抵抗指数(HOMA-IR)。结果 PCOS组25-(OH)VD3水平显著低于对照组(t=-34.61,P<0.05)。将PCOS组分为正常体重、超重及肥胖3组分析,发现正常体重者的25-(OH)VD3水平显著高于超重及肥胖组(P均<0.05)。血清25-(OH)VD3水平与E2呈正相关,与BMI、T、FPG、空腹胰岛素、HOMA-IR、TC、TG呈负相关。结论低血清25-(OH)VD3水平与PCOS密切相关,补充维生素D可能可改善PCOS患者的内分泌紊乱情况。

作者李茜西伍萍芝何琳琳吕德欣傅锦坚

机构地区广西壮族自治区柳州市妇幼保健院

出处《中国妇幼保健》 CAS 2015年第21期3636-3638,共3页 Maternal and Child Health Care of China

基金广西医药卫生自筹经费项目〔Z2014374〕

关键词 25-(OH)VD3 多囊卵巢综合征胰岛素抵抗相关性研究

分类号 R588.6 [医药卫生—内分泌]

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