妇科恶性肿瘤切除卵巢后性激素、骨密度的变化

Sex hormone and change of bone mineral density after gynecological malignant tumor resection in patients with ovarian malignant tumor

目的:探讨妇科恶性肿瘤患者切除卵巢后雌激素下降,从而导致骨密度的变化趋势及两者之间的相关关系。方法:选取月经规律组58例及妇科恶性肿瘤患者(术前均未绝经)159例进行性激素、骨密度测定。结果:妇科恶性肿瘤患者卵巢切除后出现E2下降、FSH升高,骨密度逐渐下降,均与手术绝经时间正相关。结论:妇科恶性肿瘤患者切除卵巢后,雌激素水平下降,骨量流失,骨痛、骨折等合并症逐渐增多。

Objective：To explore the estrogen decline leading to the change trend of bone mineral density in patients with gynecological malignant tumor resection of the ovarian and the relationship between the two.Methods：Sex hormone and bone mineral density were measured in 58 cases of the periods regular and 159 cases with gynecology malignant tumor（preoperative menopause）.Results：After ovarian resection,patients of gynecological malignant tumor,showed the drop in estradiol,the increase of follicle-stimulating hormone and bone mineral density decreased gradually.All were positively related to the surgical menopause time.Conclusion：After resection of the ovarian,the patients with gynecology malignant tumor may present the estrogen levels decline,bone loss,bone pain,fractures and other complications.