霍奇金淋巴瘤预后相关因素的研究进展

Research progress of prognosis factors of Hodgkin lymphoma

霍奇金淋巴瘤（HL）是一种病因及机制不明的B细胞恶性肿瘤,包括经典型HL和结节性淋巴细胞为主型HL.早期正确评估患者预后是指导个体化治疗的前提条件.目前研究证实肿瘤微环境的改变、病毒感染等因素与HL患者的预后密切相关,进一步研究HL微环境组成及病毒感染因素在HL发生、发展过程中的作用,可为HL预后评估提供新的策略.PET-CT在预测HL患者的治疗反应方面具有明显的优势,为HL预后评估开辟了一条新的途径.

Hodgkin lymphoma （HL） is a kind of B cell malignancies,which includes classic HL and nodular lymphocyte predominant HL,and there is little known about its etiology and pathogenic mechanism.To early and correctly evaluate the prognosis of patients with HL is the prerequisite to guide their individualized treatment.It has confirmed that some important factors are closely related to the prognosis of patients with HL,such as changes in tumor microenvironment and virus infection.Further research is needed to analyze the composition of tumor microenvironment and the effect of virus infection on the development of HL.These findings can provide new strategies for the prognostic evaluation of patients with HL.PET-CT imaging has obvious advantages in the prediction of treatment response and offers a new way for the assessment of prognosis in patients with HL.